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An injectable photothermally active antibacterial composite hydroxypropyl chitin hydrogel for promoting the wound healing process through photobiomodulation
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2021-5-13 , DOI: 10.1039/d1tb00724f Mengsi Ma 1 , Yalan Zhong 1 , Xulin Jiang 1
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2021-5-13 , DOI: 10.1039/d1tb00724f Mengsi Ma 1 , Yalan Zhong 1 , Xulin Jiang 1
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Prevention of bacterial infection, acceleration of wound closure and promotion of skin regeneration are crucial in the wound healing process. In this work, the photothermal activity of an injectable thermosensitive composite hydrogel based on hydroxypropyl chitin (HPCH), tannic acid (TA) and ferric ions (Fe3+) was studied. It was found that the photothermal efficiency was enhanced when the molar ratio of Fe3+/TA increased up to 20. The composite hydrogel possessed good cytocompatibility and hemocompatibility with a low dosage of the antibacterial agent TA. In vitro and in vivo antibacterial tests showed that the HPCH/TA/Fe hydrogel possessed an effective and rapid bactericidal effect with 10 minutes of near-infrared laser irradiation. Furthermore, the combination of a low-level laser therapy with the hydrogel is conducive to the acceleration of wound closure and promotion of skin tissue repair. Thus, the injectable photothermally active antibacterial composite hydrogel has great potential for the infected skin wound regeneration in clinical applications.
中文翻译：
一种可注射的光热活性抗菌复合羟丙基几丁质水凝胶通过光生物调节促进伤口愈合过程
预防细菌感染、加速伤口闭合和促进皮肤再生在伤口愈合过程中至关重要。在这项工作中，研究了基于羟丙基几丁质 (HPCH)、单宁酸 (TA) 和三价铁离子 (Fe 3+ )的可注射热敏复合水凝胶的光热活性。结果表明，当Fe 3+ /TA的摩尔比增加到20时，光热效率提高。复合水凝胶具有良好的细胞相容性和血液相容性，抗菌剂TA的用量较低。体外和体内抗菌试验表明，HPCH/TA/Fe水凝胶在10分钟的近红外激光照射下具有有效且快速的杀菌作用。此外，低强度激光疗法与水凝胶的结合有利于加速伤口闭合和促进皮肤组织修复。因此，可注射的光热活性抗菌复合水凝胶在临床应用中具有巨大的感染皮肤伤口再生潜力。
更新日期：2021-05-28
中文翻译：
一种可注射的光热活性抗菌复合羟丙基几丁质水凝胶通过光生物调节促进伤口愈合过程
预防细菌感染、加速伤口闭合和促进皮肤再生在伤口愈合过程中至关重要。在这项工作中，研究了基于羟丙基几丁质 (HPCH)、单宁酸 (TA) 和三价铁离子 (Fe 3+ )的可注射热敏复合水凝胶的光热活性。结果表明，当Fe 3+ /TA的摩尔比增加到20时，光热效率提高。复合水凝胶具有良好的细胞相容性和血液相容性，抗菌剂TA的用量较低。体外和体内抗菌试验表明，HPCH/TA/Fe水凝胶在10分钟的近红外激光照射下具有有效且快速的杀菌作用。此外，低强度激光疗法与水凝胶的结合有利于加速伤口闭合和促进皮肤组织修复。因此，可注射的光热活性抗菌复合水凝胶在临床应用中具有巨大的感染皮肤伤口再生潜力。
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