Para-toluene sulfonic acid is a typical intermediary for the synthesis of pharmaceuticals, pesticides, and dyes and is a catalyst for organic synthesis. The consumption of para-toluene sulfonic acid used in organic synthesis has increased substantially. The toluene sulfonation process is the central path for synthesizing para-toluene sulfonic acid in China. However, the process has risks and has resulted in numerous disasters. This study utilized a reaction calorimeter 1 to reproduce the commercial toluene sulfonation process in a laboratory. The para-toluene sulfonic acid product was examined with an accelerating rate calorimeter and through differential scanning calorimetry. Both differential and integral isoconversional methods were used to determine the thermal stability of and appropriate thermokinetic models for para-toluene sulfonic acid. The safety parameters of para-toluene sulfonic acid were estimated. The research findings can be used for optimization of the toluene sulfonation process and for safe handling of para-toluene sulfonic acid.

对甲苯磺酸是典型的医药、农药、染料合成中间体，是有机合成的催化剂。用于有机合成的对甲苯磺酸的消耗量大幅增加。甲苯磺化工艺是我国合成对甲苯磺酸的中心途径。然而，这个过程有风险，并导致了许​​多灾难。本研究使用反应量热仪 1 在实验室中重现商业甲苯磺化过程。用加速量热计和差示扫描量热法检测对甲苯磺酸产物。微分和积分等转化方法都用于确定对甲苯磺酸的热稳定性和合适的热动力学模型。估计了对甲苯磺酸的安全参数。研究结果可用于优化甲苯磺化工艺和安全处理对甲苯磺酸。