Objective

To explore predictors of severe COVID-19 disease in patients with diabetes hospitalized for COVID-19.

Methods

This is a retrospective observational study of adults with diabetes admitted for COVID-19. Bivariate tests and multivariable Cox regression were used to identify risk factors for severe COVID-19, defined as a composite endpoint of intensive care unit admission/intubation or in-hospital death.

Results

In 1134 patients with diabetes admitted for COVID-19, more severe disease was associated with older age (HR 1.02, p < 0.001), male sex (HR 1.28, p = 0.017), Asian race (HR 1.34, p = 0.029 [reference: white]), and greater obesity (moderate obesity HR 1.59, p = 0.015; severe obesity HR 2.07, p = 0.002 [reference: normal body mass index]). Outpatient diabetes medications were not associated with outcomes.

Conclusions

Age, male sex, Asian race, and obesity were associated with increased risk of severe COVID-19 disease in adults with type 2 diabetes hospitalized for COVID-19.

Summary

In patients with type 2 diabetes hospitalized for COVID-19 disease, we observed that age, male sex, Asian race, and obesity predicted severe COVID-19 outcomes of intensive care unit admission, intubation, or in-hospital death. The risk conferred by obesity increased with worsening obesity. Outpatient diabetes medications were not observed to be significant predictors of study outcomes.

中文翻译：

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糖尿病患者重症 COVID-19 的入院前预测因素

 客观的

探讨因 COVID-19 住院的糖尿病患者的严重 COVID-19 疾病的预测因素。

 方法

这是一项针对因 COVID-19 入院的成人糖尿病患者的回顾性观察研究。使用双变量测试和多变量 Cox 回归来确定严重 COVID-19 的危险因素，定义为重症监护病房入院/插管或院内死亡的复合终点。

 结果

在 1134 名因 COVID-19 入院的糖尿病患者中，更严重的疾病与年龄较大（HR 1.02，p < 0.001）、男性（HR 1.28，p = 0.017）、亚洲人种（HR 1.34，p = 0.029）相关[参考：白色]），以及更大的肥胖（中度肥胖 HR 1.59，p = 0.015；重度肥胖 HR 2.07，p = 0.002 [参考：正常体重指数]）。门诊糖尿病药物与结果无关。

 结论

年龄、男性、亚洲种族和肥胖与因 COVID-19 住院的 2 型糖尿病成人患者患严重 COVID-19 疾病的风险增加相关。

 概括

在因 COVID-19 疾病住院的 2 型糖尿病患者中，我们观察到年龄、男性、亚洲种族和肥胖可预测重症监护室入院、插管或院内死亡的严重 COVID-19 结局。肥胖带来的风险随着肥胖的恶化而增加。没有观察到门诊糖尿病药物是研究结果的显着预测因素。