Acetic acid stress in budding yeast: From molecular mechanisms to applications,Yeast

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Acetic acid stress in budding yeast: From molecular mechanisms to applications
Yeast ( IF 2.2 ) Pub Date : 2021-05-17 , DOI: 10.1002/yea.3651
Nicoletta Guaragnella _{1,

2} , Maurizio Bettiga _{3,

4}

Affiliation

Acetic acid stress represents a frequent challenge to counteract for yeast cells under several environmental conditions and industrial bioprocesses. The molecular mechanisms underlying its response have been mostly elucidated in the budding yeast Saccharomyces cerevisiae, where acetic acid can be either a physiological substrate or a stressor. This review will focus on acetic acid stress and its response in the context of cellular transport, pH homeostasis, metabolism and stress-signalling pathways. This information has been integrated with the results obtained by multi-omics, synthetic biology and metabolic engineering approaches aimed to identify major cellular players involved in acetic acid tolerance. In the production of biofuels and renewable chemicals from lignocellulosic biomass, the improvement of acetic acid tolerance is a key factor. In this view, how this knowledge could be used to contribute to the development and competitiveness of yeast cell factories for sustainable applications will be also discussed.

中文翻译：

出芽酵母中的乙酸胁迫：从分子机制到应用

在几种环境条件和工业生物过程中，醋酸胁迫代表了对抗酵母细胞的常见挑战。其反应的分子机制主要在出芽酵母酿酒酵母中得到阐明，其中乙酸可以是生理底物或压力源。本综述将重点关注乙酸应激及其在细胞运输、pH 稳态、代谢和应激信号通路背景下的反应。该信息已与多组学、合成生物学和代谢工程方法获得的结果相结合，旨在确定参与醋酸耐受性的主要细胞参与者。在从木质纤维素生物质生产生物燃料和可再生化学品的过程中，提高乙酸耐受性是一个关键因素。从这个角度来看，还将讨论如何利用这些知识来促进酵母细胞工厂可持续应用的发展和竞争力。

更新日期：2021-07-01

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