Fe₃O₄-loaded ion exchange resin composites (Fe₃O₄@Resin) were optimally constructed through ion exchange and co-precipitation of Fe²⁺ and Fe³⁺ on strong acid ion exchange resin. The as-synthesized Fe₃O₄@Resin composite was characterized and investigated for ¹⁰B/¹¹B separation including effect of pH and isotherms through batch adsorption experiments which can be well described by Langmuir model. In the chromatographic column packed with Fe₃O₄@Resin, ¹⁰B was selectively retained with a high dynamic separation factor of 1.312. Considering the consistency between simulated and experimental breakthrough curves within Fe₃O₄@Resin packed column, chromatographic ¹⁰B/¹¹B separation performance was simulated under various conditions which were further optimized by Response surface methodology. Consequently, the annual yield of ¹⁰B reached the maximum of 2534 g with feed concentration of 9.729 g L^↙1, flow rate of 146.05 mL min^↙1, and column size of 2.2 Ô 150 cm (I.D. Ô length). In addition, five-cycle adsorption/regeneration experiments demonstrated its merit of reusability.

Fe ₃ O ₄负载的离子交换树脂复合材料（Fe ₃ O ₄ @Resin）通过离子交换和Fe ²⁺和Fe ³⁺在强酸性离子交换树脂上的共沉淀优化构建。通过分批吸附实验对合成的 Fe ₃ O ₄ @Resin 复合材料进行表征和研究，用于¹⁰ B/ ¹¹ B 分离，包括p H 和等温线的影响，朗缪尔模型可以很好地描述这些实验。在填充有 Fe ₃ O ₄ @Resin 的色谱柱中，¹⁰B 被选择性保留，具有 1.312 的高动态分离因子。考虑到 Fe ₃ O ₄ @Resin 填充柱内模拟和实验穿透曲线的一致性，在各种条件下模拟了色谱¹⁰ B/ ¹¹ B 分离性能，并通过响应面方法进一步优化。因此，在进料浓度为 9.729 g L ^↙1，流速为 146.05 mL min ^↙1，柱尺寸为 2.2 Ô 150 cm（ID Ô 长度）的情况下，¹⁰ B的年产量达到了最大值 2534 g 。此外，五循环吸附/再生实验证明了其可重复使用的优点。