Cell Calcium ( IF 4.3 ) Pub Date : 2021-05-28 , DOI: 10.1016/j.ceca.2021.102422 Alejandro Marmolejo-Garza 1 , Amalia M Dolga 2
|
Ferroptosis is a form of programmed cell death with particular hallmarks, such as oxidative stress, increased calcium fluxes, and altered cellular morphology. In ferroptosis, the disruption of plasma membrane is the step that culminates into cell death. By inducing ferroptosis with Erastin-1 and RSL3 in various human cellular models, Pedrera et al. tracked the behaviour of several hallmarks of ferroptosis and demonstrated that lipid peroxidation precedes cytosolic calcium rise and plasma membrane breakdown, which is dependent on nanopore formation. Ferroptotic cell death is inhibited by osmotically active protectants of proper size that can prevent water flux through nanopores.
中文翻译：
PEG 在 ESCTIII 的帮助下通过毛孔排出
铁死亡是一种程序性细胞死亡形式，具有特定的特征，例如氧化应激、钙通量增加和细胞形态改变。在铁死亡中，质膜的破坏是最终导致细胞死亡的步骤。 Pedrera 等人通过在各种人类细胞模型中使用 Erastin-1 和 RSL3 诱导铁死亡。追踪了铁死亡的几个标志的行为，并证明脂质过氧化先于细胞质钙上升和质膜分解，这取决于纳米孔的形成。适当大小的渗透活性保护剂可以抑制铁死亡细胞死亡，这些保护剂可以阻止水通过纳米孔。
京公网安备 11010802027423号