Objectives It is unclear whether body weight status (underweight/normal weight/overweight/obese) is associated with allergic disease. Our objective was to investigate the relationship between body weight status (body mass index; BMI) and atopic allergic disease in prepubertal children, and to compare children with atopic allergic diseases with non atopic healthy children. Methods A prospective cross sectional study of 707 prepubertal children aged 3–10 years was performed; the participants were 278 atopic children with physician-diagnosed allergic disease (allergic rhinitis and asthma) (serum total IgE level >100 kU/l and eosinophilia >4%, or positivity to at least one allergen in skin test) and 429 non atopic healthy age- and sex-matched controls. Data were collected between December 2019 and November 2020 at the Pediatric General and Pediatric Allergy Outpatient Clinics of Bezmialem Vakıf University Hospital. Results Underweight was observed in 11.6% of all participants (10.8% of atopic children, 12.2% of healthy controls), and obesity in 14.9% of all participants (18.0% of atopic children, 12.8% of controls). Obese (OR 1.71; 95% CI: 1.08–2.71, p=0.021), and overweight status (OR 1.62; 95% CI: 1.06–2.50, p=0.026) were associated with an increased risk of atopic allergic disease compared to normal weight in pre-pubertal children. This association did not differ by gender. There was no relationship between underweight status and atopic allergic disease (OR 1.03; 95% CI: 0.63–1.68, p=0.894). Conclusions Overweight and obesity were associated with an increased risk of atopic allergic disease compared to normal weight among middle-income and high-income pre pubertal children living in Istanbul.

中文翻译：

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超重/肥胖是青春期前儿童特应性过敏性疾病的危险因素吗？病例对照研究

目的 体重状态（体重不足/正常体重/超重/肥胖）是否与过敏性疾病有关尚不清楚。我们的目的是调查青春期前儿童的体重状态（体重指数；BMI）与特应性过敏性疾病之间的关系，并将特应性过敏性疾病儿童与非特应性过敏性疾病儿童进行比较。方法 对 707 名 3-10 岁青春期前儿童进行前瞻性横断面研究；参与者是 278 名患有医生诊断的过敏性疾病（过敏性鼻炎和哮喘）（血清总 IgE 水平 >100 kU/l 和嗜酸性粒细胞增多 >4%，或皮肤试验中至少对一种过敏原呈阳性）的特应性儿童和 429 名非特应性健康儿童年龄和性别匹配的对照。数据是在 2019 年 12 月至 2020 年 11 月期间在 Bezmialem Vakıf 大学医院的儿科综合和儿科过敏门诊收集的。结果在所有参与者中，体重过轻的比例为11.6％（特应性儿童为10.8％，健康对照者为12.2％），在所有参与者中，肥胖为14.9％（特应性儿童为18.0％，对照组为12.8％）。与正常人相比，肥胖（OR 1.71；95% CI：1.08–2.71，p=0.021）和超重状态（OR 1.62；95% CI：1.06–2.50，p=0.026）与特应性过敏性疾病风险增加相关青春期前儿童的体重。这种关联没有性别差异。体重不足与特应性过敏性疾病之间没有关系（OR 1.03；95% CI：0.63–1.68，p=0.894）。