Objectives The benefits of gonadotropin-releasing hormone analogues (GnRHa) in the treatment of central precocious puberty are well established, and their use is regarded as both safe and effective. Possible adverse effects on blood pressure (BP) and cardiac outcomes, body composition, bone health and brain development, however, continue to be of some concern. The aim of this study was to analyze BP changes in transgender female adolescents before and after receiving GnRHa and after adding estrogen treatment. Methods This was a retrospective pilot study. We analyzed systolic BP (SBP) and diastolic BP (DBP) before and after GnRHa initiation and after adding estrogen. Results Nineteen transgender female adolescents received GnRHa and 15 continued to estrogen treatment. Their baseline SBP and DBP percentiles did not change significantly after either GnRHa or the addition of estrogen treatment. Conclusions Blood pressure is apparently not affected by GnRHa or GnRHa + estrogen treatment in transgender female adolescents. Further larger studies are indicated to confirm these findings.

中文翻译：

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跨性别女性青少年青春期抑制促性腺激素释放激素类似物继以雌二醇治疗后的血压动态：一项初步研究

目的 促性腺激素释放激素类似物 (GnRHa) 在治疗中枢性性早熟中的益处已得到公认，并且它们的使用被认为既安全又有效。然而，对血压（BP）和心脏预后，身体组成，骨骼健康和大脑发育的可能不利影响仍然令人担忧。本研究的目的是分析接受 GnRHa 治疗前后和添加雌激素治疗后跨性别女性青少年的血压变化。方法 这是一项回顾性试点研究。我们分析了GnRHa启动前后，添加雌激素后的收缩压（SBP）和舒张压（DBP）。结果19例变性女性青少年接受了GnRHa治疗，其中15例继续接受雌激素治疗。在 GnRHa 或添加雌激素治疗后，他们的基线 SBP 和 DBP 百分位数没有显着变化。结论 GnRHa或GnRHa+雌激素治疗对跨性别女性青少年的血压明显没有影响。进一步更大规模的研究将证实这些发现。