New derivatives of isopimaric acid at the carboxylic acid were prepared. Their analgesic activity was studied in models of visceral and thermal pain. Isopimaric acid amides with aminoethanol and (2R)-(hydroxymethyl)pyrrolidine groups exhibited statistically significant analgesic activity in acetic acid-induced writhing (5 and 25 mg/kg doses) and hot-plate tests (25 mg/kg dose) that was comparable to that of diclofenac sodium (10 mg/kg dose). The new agents were characterized by low (LD₅₀ > 1250 mg/kg) in vivo toxicity. Molecular modeling of possible interaction of the most active compounds with transmembrane G-protein-binding cannabinoid receptor CB₂ was performed.

制备了异海松酸羧酸的新衍生物。在内脏痛和热痛模型中研究了它们的镇痛活性。异海松酸酰胺与氨基乙醇和 (2 R )-（羟甲基）吡咯烷组在乙酸诱导的扭体（5 和 25 mg/kg 剂量）和热板试验（25 mg/kg 剂量）中表现出统计学上显着的镇痛活性。与双氯芬酸钠（10 mg/kg 剂量）相当。新药剂的特点是体内毒性低（LD ₅₀ > 1250 mg/kg）。对最活跃的化合物与跨膜 G 蛋白结合大麻素受体 CB ₂的可能相互作用进行了分子建模。