Accurate documentation of the associations between stress disorders and suicide attempts provides important information about a high-risk population and target group for preventative interventions. In this case-cohort study, cases were all individuals born or residing in Denmark who made a nonfatal suicide attempt during 1995–2015 (n = 22,974). The comparison subcohort included a 5% random sample of the Danish population on January 1, 1995 (n = 265,183). Stress disorder diagnoses and suicide attempts were identified using ICD-10 codes from national medical registries. The presence of any stress disorder substantially increased the rate of suicide attempts versus the comparison subcohort, rate per 100,000 person-years (PYs) = 604 vs. 13. We observed associations between each type of stress disorder and suicide attempts, hazard ratios (HRs) = 10.1–37.6, even after adjustment for potential confounders, adjusted HRs = 1.8–8.3, with the strongest associations for adjustment disorder relative to other diagnoses. After adjusting for demographic and health variables, the rate of suicide attempts among individuals with any stress disorder diagnosis was nearly 13 times the suicide attempt rate in the comparison cohort. A bias analysis demonstrated that associations remained robust despite potential differential misclassification of suicide attempts. Study strengths included the use of individual-level data linked across administrative and medical registries in the setting of universal health care and the use of longitudinal analyses capturing data over 20 years. The study demonstrated associations between the full range of stress disorders and suicide attempts, extending research specific to posttraumatic stress disorder.

中文翻译：

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丹麦人口中的压力障碍和非致命自杀未遂的风险

准确记录应激障碍与自杀未遂之间的关联，可提供有关高危人群和预防性干预目标群体的重要信息。在这项病例队列研究中，病例是在 1995 年至 2015 年期间尝试过非致命自杀的所有出生或居住在丹麦的个人 ( n = 22,974)。比较子队列包括 1995 年 1 月 1 日丹麦人口的 5% 随机样本（n = 265,183）。使用ICD-10识别压力障碍诊断和自杀未遂来自国家医疗登记处的代码。与比较子队列相比，任何压力障碍的存在都会显着增加自杀未遂率，每 100,000 人年 (PY) = 604 对 13。我们观察到每种类型的压力障碍与自杀未遂之间的关联，风险比 ( HR s) = 10.1–37.6，即使在针对潜在混杂因素进行调整后，调整后的HRs = 1.8–8.3，相对于其他诊断与适应障碍的关联最强。在调整人口统计和健康变量后，患有任何压力障碍诊断的个体的自杀未遂率几乎是比较队列中自杀未遂率的 13 倍。偏差分析表明，尽管自杀未遂可能存在不同的错误分类，但关联仍然很强。研究优势包括在全民医疗保健环境中使用跨行政和医疗登记处链接的个人层面数据，以及使用纵向分析捕获 20 多年的数据。该研究证明了各种应激障碍与自杀未遂之间的关联，扩展了针对创伤后应激障碍的研究。