Global and local brain connectivity changes associated with sudden unilateral sensorineural hearing loss,NMR in Biomedicine

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Global and local brain connectivity changes associated with sudden unilateral sensorineural hearing loss
NMR in Biomedicine ( IF 2.7 ) Pub Date : 2021-05-27 , DOI: 10.1002/nbm.4544
Silvia Minosse ₁ , Francesco Garaci _{2,

3} , Federica Martino ₄ , Roberta Di Mauro _{4,

5} , Milena Melis ₂ , Francesca Di Giuliano ₂ , Eliseo Picchi ₆ , Maria Guerrisi ₁ , Roberto Floris ₆ , Stefano Di Girolamo ₄ , Nicola Toschi _{1,

7}

Affiliation

Recent studies suggest that even moderate sudden sensorineural hearing loss (SSNHL) causes reduction of gray matter volume in the primary auditory cortex, diminishing its ability to react to sound stimulation, as well as reorganization of functional brain networks. We employed resting-state functional MRI (rs-fMRI), in conjunction with graph-theoretical analysis and a newly developed functional “disruption index,” to study whole-brain as well as local functional changes in patients with unilateral SSNHL. We also assessed the potential of graph-theoretical measures as biomarkers of disease, in terms of their relationship to clinically relevant audiological parameters. Eight patients with moderate or severe unilateral SSNHL and 15 healthy controls were included in this prospective pilot study. All patients underwent rs-fMRI to study potential changes in brain connectivity. From rs-fMRI data, global and local graph-theoretical measures, disruption index, and audiological examinations were estimated. Mann-Whitney U tests were used to study the differences between SSNHL patients and healthy controls. Associations between brain metrics and clinical variables were studied using multiple linear regressions, and the presence or absence of brain network hubs was assessed using Fisher's exact test. No statistically significant differences between SSNHL patients and healthy controls were found in global or local network measures. However, when analyzing brain networks through the disruption index, we found a brain-wide functional network reorganization (p < 0.001 as compared with controls), whose extent was associated with clinical impairment (p < 0.05). We also observed several functional hubs in SSNHL patients that were not present in healthy controls and vice versa. Our results demonstrate a brain involvement in SSNHL patients, not detectable using conventional graph-theoretical analysis, which may yield subtle disease clues and possibly aid in monitoring disease progression in clinical trials.

中文翻译：

与突发性单侧感音神经性听力损失相关的全局和局部大脑连接变化

最近的研究表明，即使是中度的突发性感觉神经性听力损失 (SSNHL) 也会导致初级听觉皮层的灰质体积减少，从而降低其对声音刺激的反应能力，以及功能性大脑网络的重组。我们采用静息状态功能 MRI (rs-fMRI) 结合图论分析和新开发的功能“中断指数”来研究单侧 SSNHL 患者的全脑和局部功能变化。我们还评估了图论测量作为疾病生物标志物的潜力，就其与临床相关听力学参数的关系而言。这项前瞻性试验研究包括 8 名中度或重度单侧 SSNHL 患者和 15 名健康对照者。所有患者都接受了 rs-fMRI 以研究大脑连接的潜在变化。根据 rs-fMRI 数据，估计了全局和局部图形理论测量值、中断指数和听力学检查。曼-惠特尼U检验用于研究SSNHL患者和健康对照之间的差异。使用多元线性回归研究大脑指标和临床变量之间的关联，并使用 Fisher 精确检验评估大脑网络中枢的存在与否。在全球或本地网络测量中，未发现 SSNHL 患者和健康对照之间存在统计学上的显着差异。然而，当通过中断指数分析大脑网络时，我们发现全脑功能网络重组（与对照组相比p < 0.001），其程度与临床损伤相关（p < 0.05)。我们还在 SSNHL 患者中观察到健康对照中不存在的几个功能中心，反之亦然。我们的结果表明 SSNHL 患者的大脑受累，使用传统的图论分析无法检测到，这可能会产生微妙的疾病线索，并可能有助于监测临床试验中的疾病进展。

更新日期：2021-07-02

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