ALK-rearranged histiocytosis: Report of two cases with involvement of the central nervous system,Neuropathology and Applied Neurobiology

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ALK-rearranged histiocytosis: Report of two cases with involvement of the central nervous system
Neuropathology and Applied Neurobiology ( IF 5 ) Pub Date : 2021-05-28 , DOI: 10.1111/nan.12739
Sabrina Rossi ₁ , Marco Gessi ₂ , Sabina Barresi ₁ , Gianpiero Tamburrini ₃ , Isabella Giovannoni ₁ , Antonio Ruggiero ₄ , Giovanna Stefania Colafati ₅ , Paolo Frassanito ₃ , Alessia Carboni ₅ , Andrea Alexandre ₆ , Antonella Cacchione ₇ , Pietro Trombatore ₆ , Francesca Diomedi-Camassei ₁ , Stefania Gaspari ₇ , Francesca Gianno _{8,

9} , Carlo Efisio Marras ₁₀ , Valerio Cecinati ₁₁ , Andrea Carai ₁₀ , Angela Mastronuzzi ₇ , Rita Alaggio ₁

Affiliation

Pathology Unit, Department of Laboratories, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Neuropathology Unit, Pathology Division, Fondazione Policlinico Universitario A.Gemelli IRCCS, Università Cattolica S.Cuore, Rome, Italy.
Pediatric Neurosurgery Unit, Fondazione Policlinico Universitario A.Gemelli IRCCS, Università Cattolica S.Cuore, Rome, Italy.
Pediatric Oncology Division, Fondazione Policlinico Universitario A.Gemelli IRCCS, Università Cattolica S.Cuore, Rome, Italy.
Neuroradiology Unit, Imaging Department, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Radiology and Neuroradiology Division, Fondazione Policlinico Universitario A.Gemelli IRCCS, Università Cattolica S.Cuore, Rome, Italy.
Department of Onco-Hematology, Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Department of Radiology, Oncology and Anatomic Pathology, University La Sapienza, Rome, Italy.
IRCCS Neuromed, Pozzilli, Isernia, Italy.
Neurosurgery Unit, Department of Neuroscience and Neurorehabilitation, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Pediatrics and Pediatric Oncoematology Unit, Ospedale Santissima Anninziata, Taranto, Italy.

Histiocytoses are a heterogeneous group of localized or disseminated diseases. Clinical presentation and patients' outcome vary greatly, ranging from mild to life-threatening disorders. Rare cases of systemic or localized histiocytosis harboring ALK rearrangement have been reported.

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