ABSTRACT

Introduction

Coenzyme Q10 (CoQ10) is an antioxidant molecule with anti-aging activity on human hair, and because of its pharmaceutical limitations such as large molecular weight, high lipophilicity and poor water solubility, its therapeutic effectiveness has been hampered. Therefore, different vesicular nanocarriers were developed in the current work, for enhancement of the skin penetration of CoQ10 for treatment of androgenic alopecia.

Areas covered

In order to overcome the poor skin penetration of CoQ10, it was formulated in liposomes, transfersomes, ethosomes, cerosomes and transethosomes using the thin-film hydration method. Results revealed that transethosomes were the carrier of choice for CoQ10, in which it displayed a particle size of 146 nm, zeta potential −55 mV and entrapment efficiency of 97.63%. Transethosomes also achieved the highest deposition percentage for CoQ10, exceeding 95% in the different skin layers. Upon clinical examination in patients suffering from androgenic alopecia, CoQ10 transethosomes displayed better clinical response than the administration of CoQ10 solution, which was further confirmed by dermoscopic examination.

Expert opinion

Findings of this study further prove that loading antioxidants such as CoQ10 in nanocarriers maximizes their therapeutic efficiency, and opens many opportunities for their application in treatment of several other topical diseases.

中文翻译：

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用于治疗雄激素性脱发的辅酶 Q10 磷脂囊泡制剂：体外渗透和临床评价

摘要

介绍

辅酶Q10（CoQ10）是一种对人发具有抗衰老活性的抗氧化分子，由于其分子量大、亲脂性高、水溶性差等药物局限性，阻碍了其治疗效果。因此，在目前的工作中开发了不同的囊泡纳米载体，用于增强 CoQ10 的皮肤渗透，以治疗雄激素性脱发。

覆盖区域

为了克服 CoQ10 皮肤渗透性差的问题，使用薄膜水化方法将其配制在脂质体、转移体、脂质体、蜡质体和转脂质体中。结果表明，transethosomes 是 CoQ10 的首选载体，其粒径为 146 nm，zeta 电位为 -55 mV，截留效率为 97.63%。Transethosomes 的 CoQ10 沉积百分比也最高，在不同的皮肤层中超过 95%。在对雄激素性脱发患者进行临床检查后，CoQ10 transethosomes 显示出比 CoQ10 溶液更好的临床反应，皮肤镜检查进一步证实了这一点。

专家意见

这项研究的结果进一步证明，在纳米载体中装载 CoQ10 等抗氧化剂可以最大限度地提高其治疗效率，并为其在其他几种局部疾病的治疗中的应用开辟了许多机会。