Over the years, interleukin (IL)-27 has received much attention because of its highly divergent, sometimes even opposing, functions in immunity. IL-30, the p28 subunit that forms IL-27 together with Ebi3 and is also known as IL-27p28 or IL-27A, has been considered a surrogate to represent IL-27. However, it was later discovered that IL-30 can form complexes with other protein subunits, potentially leading to overlapping or discrete functions. Furthermore, there is emerging evidence that IL-30 itself may perform immunomodulatory functions independent of Ebi3 or other binding partners and that IL-30 production is strongly associated with certain cancers in humans. In this review, we will discuss the biology of IL-30 and other IL-30-associated cytokines and their functions in inflammation and cancer.

多年来，白细胞介素 (IL)-27 因其在免疫中的高度不同，有时甚至是相反的功能而备受关注。IL-30 是与 Ebi3 一起形成 IL-27 的 p28 亚基，也称为 IL-27p28 或 IL-27A，被认为是代表 IL-27 的替代物。然而，后来发现 IL-30 可以与其他蛋白质亚基形成复合物，可能导致功能重叠或离散。此外，有新的证据表明，IL-30 本身可以发挥独立于 Ebi3 或其他结合伙伴的免疫调节功能，并且 IL-30 的产生与人类的某些癌症密切相关。在这篇综述中，我们将讨论 IL-30 和其他 IL-30 相关细胞因子的生物学及其在炎症和癌症中的功能。