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Experimental study on antiepileptic action of Kousheyashma Bhasma
Indian Journal of Traditional Knowledge ( IF 0.7 ) Pub Date : 2021-05-27
M M Nidhin, Sharma K Govinda, S Bhat, G G Chaitra

Epilepsy is one of the most common neurological diseases. It is characterised by recurrent episodes of disturbance in movement, sensation and consciousness. With the increased incidence rate of epilepsy, a number of treatment modalities as well as formulations are being developed in recent years. In Ayurveda also many formulations are available for the treatment of epilepsy. However, there is a search of formulations which can show quick and longstanding efficacy on epilepsy. Kousheyashma is a mineral drug used in Ayurveda pharmaceutics. It is yellowish white and is identified as asbestos. Magnesium, calcium and silicate are the chief chemical entity of this drug. It is an easily and abundantly available mineral in India. The Bhasma is economic as the pharmaceutical processing of it is easy. In the pharmacological and therapeutic properties of this drug, it is mentioned that it has anti-epileptic activity. However, there is no substantial evidence to prove the antiepileptic activity of Kousheyashma. Hence, the present study was undertaken to experimentally evaluate the efficacy of Kousheyashma Bhasma in epilepsy. Antiepileptic activity was evaluated in Swiss albino mice by two methods namely Pentylenetetrazol (PTZ)-induced seizure method and kindling PTZ-induced seizure method. Mice selected based on exclusion and inclusion criteria were randomly allocated into five groups. Mice were subjected to chemo convulsions by injecting PTZ intraperitoneally and observed for 35 min to analyse convulsion behaviours. Kousheyashma Bhasma has shown statistically significant results in PTZ-induced epileptic symptoms in Swiss albino mice.

中文翻译:

苦瓜抗癫痫作用的实验研究

癫痫病是最常见的神经系统疾病之一。它的特征是反复出现运动,感觉和意识障碍。随着癫痫发病率的增加,近年来正在开发许多治疗方法和制剂。在阿育吠陀中,许多制剂可用于治疗癫痫。然而,正在寻找可以显示出对癫痫的快速且长期的功效的制剂。Kousheyashma是阿育吠陀制药中使用的一种矿物质。它是淡黄色白色,被识别为石棉。镁,钙和硅酸盐是该药物的主要化学实体。它是印度容易和大量获得的矿物。Bhasma很经济,因为它的制药过程很容易。在该药物的药理和治疗特性中,提到它具有抗癫痫活性。但是,没有实质性证据证明Kousheyashma的抗癫痫活性。因此,本研究旨在通过实验评估Kousheyashma Bhasma在癫痫症中的疗效。通过两种方法评估瑞士白化病小鼠的抗癫痫活性,即戊四氮(PTZ)诱发的癫痫发作方法和点燃PTZ诱发的癫痫发作方法。根据排除和纳入标准选择的小鼠被随机分为五组。通过腹膜内注射PTZ对小鼠进行化学惊厥,并观察35分钟以分析惊厥行为。Kousheyashma Bhasma已在瑞士白化病小鼠的PTZ诱发的癫痫症状中显示出统计学上显着的结果。提到它具有抗癫痫活性。但是,没有实质性证据证明Kousheyashma的抗癫痫活性。因此,本研究旨在通过实验评估Kousheyashma Bhasma在癫痫症中的疗效。通过两种方法评估瑞士白化病小鼠的抗癫痫活性,即戊四氮(PTZ)诱发的癫痫发作方法和点燃PTZ诱发的癫痫发作方法。根据排除和纳入标准选择的小鼠被随机分为五组。通过腹膜内注射PTZ对小鼠进行化学惊厥,并观察35分钟以分析惊厥行为。Kousheyashma Bhasma已在瑞士白化病小鼠的PTZ诱发的癫痫症状中显示出统计学上显着的结果。提到它具有抗癫痫活性。但是,没有实质性证据证明Kousheyashma的抗癫痫活性。因此,本研究旨在通过实验评估Kousheyashma Bhasma在癫痫症中的疗效。通过两种方法对瑞士白化病小鼠的抗癫痫活性进行了评估,即戊四氮(PTZ)诱导的癫痫发作方法和点燃PTZ诱导的癫痫发作方法。根据排除和纳入标准选择的小鼠被随机分为五组。通过腹膜内注射PTZ对小鼠进行化学惊厥,并观察35分钟以分析惊厥行为。Kousheyashma Bhasma已在瑞士白化病小鼠的PTZ诱发的癫痫症状中显示出统计学上显着的结果。没有实质性证据证明Kousheyashma的抗癫痫活性。因此,本研究旨在通过实验评估Kousheyashma Bhasma在癫痫症中的疗效。通过两种方法评估瑞士白化病小鼠的抗癫痫活性,即戊四氮(PTZ)诱发的癫痫发作方法和点燃PTZ诱发的癫痫发作方法。根据排除和纳入标准选择的小鼠被随机分为五组。通过腹膜内注射PTZ对小鼠进行化学惊厥,并观察35分钟以分析惊厥行为。Kousheyashma Bhasma已在瑞士白化病小鼠的PTZ诱发的癫痫症状中显示出统计学上显着的结果。没有实质性证据证明Kousheyashma的抗癫痫活性。因此,本研究旨在通过实验评估Kousheyashma Bhasma在癫痫症中的疗效。通过两种方法评估瑞士白化病小鼠的抗癫痫活性,即戊四氮(PTZ)诱发的癫痫发作方法和点燃PTZ诱发的癫痫发作方法。根据排除和纳入标准选择的小鼠被随机分为五组。通过腹膜内注射PTZ对小鼠进行化学惊厥,并观察35分钟以分析惊厥行为。Kousheyashma Bhasma已在瑞士白化病小鼠的PTZ诱发的癫痫症状中显示出统计学上显着的结果。本研究旨在通过实验评估Kousheyashma Bhasma在癫痫中的疗效。通过两种方法评估瑞士白化病小鼠的抗癫痫活性,即戊四氮(PTZ)诱发的癫痫发作方法和点燃PTZ诱发的癫痫发作方法。根据排除和纳入标准选择的小鼠被随机分为五组。通过腹膜内注射PTZ对小鼠进行化学惊厥,并观察35分钟以分析惊厥行为。Kousheyashma Bhasma已在瑞士白化病小鼠的PTZ诱发的癫痫症状中显示出统计学上显着的结果。本研究旨在通过实验评估Kousheyashma Bhasma在癫痫中的疗效。通过两种方法评估瑞士白化病小鼠的抗癫痫活性,即戊四氮(PTZ)诱发的癫痫发作方法和点燃PTZ诱发的癫痫发作方法。根据排除和纳入标准选择的小鼠被随机分为五组。通过腹膜内注射PTZ对小鼠进行化学惊厥,并观察35分钟以分析惊厥行为。Kousheyashma Bhasma已在瑞士白化病小鼠的PTZ诱发的癫痫症状中显示出统计学上显着的结果。根据排除和纳入标准选择的小鼠被随机分为五组。通过腹膜内注射PTZ对小鼠进行化学惊厥,并观察35分钟以分析惊厥行为。Kousheyashma Bhasma已在瑞士白化病小鼠的PTZ诱发的癫痫症状中显示出统计学上显着的结果。根据排除和纳入标准选择的小鼠被随机分为五组。通过腹膜内注射PTZ对小鼠进行化学惊厥,并观察35分钟以分析惊厥行为。Kousheyashma Bhasma已在瑞士白化病小鼠的PTZ诱发的癫痫症状中显示出统计学上显着的结果。
更新日期:2021-05-27
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