I analyse the origin of the genetic code in the light of the evolution of biological catalysts. I discuss the rudimentary forms that the genetic code assumed in the presence of a catalysis performed by ions or by low molecular weight molecules, such as nucleotide coenzymes. However, it is only with the advent of a mixed polymer made of RNA and peptides - covalently linked - that the genetic code took on a clearer form. Indeed, the first true form of coding appeared. Furthermore, interacting peptidated RNAs promoted an extremely rudimentary form of protein synthesis. This stage evolved into a stage in which proto-mRNAs guided interactions among peptidated RNAs aimed at the synthesis of peptidated RNAs having an active catalytic function. Finally, the invasion of aminoacylated proto-tRNAs with specific amino acids, coming from amino acid metabolism, and recognising only three bases on these proto-mRNAs with reading frames larger than three bases, would have triggered the birth of actual mRNAs, i.e. the origin of codons. All this would have linked the metabolism of amino acids to the origin of mRNAs and therefore to the origin of the organization of the genetic code, as maintained by the coevolution theory of the genetic code.

我根据生物催化剂的进化来分析遗传密码的起源。我讨论了在由离子或低分子量分子（例如核苷酸辅酶）进行催化的情况下遗传密码假定的基本形式。然而，只有随着由 RNA 和肽共价连接的混合聚合物的出现，遗传密码才呈现出更清晰的形式。事实上，第一种真正的编码形式出现了。此外，相互作用的肽化 RNA 促进了一种极其基本的蛋白质合成形式。该阶段演变为原mRNA指导肽化RNA之间相互作用的阶段，旨在合成具有活性催化功能的肽化RNA。最后，来自氨基酸代谢的具有特定氨基酸的氨酰化原 tRNA 的入侵，并且仅识别这些原始 mRNA 上具有大于三个碱基的阅读框的三个碱基，将触发实际 mRNA 的诞生，即密码子的起源。所有这些都将氨基酸的代谢与 mRNA 的起源联系起来，因此与遗传密码的组织起源联系起来，正如遗传密码的共同进化理论所支持的那样。