The purpose of this study is to assess the relationship between regional white matter diffusion imaging changes and finite element strain measures in nonconcussed youth football players. Pre- and post-season diffusion-weighted imaging was performed in 102 youth football subject-seasons, in which no concussions were diagnosed. The diffusion data were normalized to the IXI template. Percent change in fractional anisotropy (%ΔFA) images were generated. Using data from the head impact telemetry system, the cumulative maximum principal strain one times strain rate (CMPS1 × SR), a measure of the cumulative tensile brain strain and strain rate for one season, was calculated for each subject. Two linear regression analyses were performed to identify significant positive or inverse relationships between CMPS1 × SR and %ΔFA within the international consortium for brain mapping white matter mask. Age, body mass index, days between pre- and post-season imaging, previous brain injury, attention disorder diagnosis, and imaging protocol were included as covariates. False discovery rate correction was used with corrected alphas of 0.025 and voxel thresholds of zero. Controlling for all covariates, a significant, positive linear relationship between %ΔFA and CMPS1 × SR was identified in the bilateral cingulum, fornix, internal capsule, external capsule, corpus callosum, corona radiata, corticospinal tract, cerebral and middle cerebellar peduncle, superior longitudinal fasciculus, and right superior fronto-occipital fasciculus. Post hoc analyses further demonstrated significant %ΔFA differences between high-strain football subjects and noncollision control athletes, no significant %ΔFA differences between low-strain subjects and noncollision control athletes, and that CMPS1 × SR significantly explained more %ΔFA variance than number of head impacts alone.

中文翻译：

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非脑震荡青少年足球运动员中与累积拉伸应变和应变率相关的区域白质扩散变化


本研究的目的是评估非脑震荡青少年足球运动员的区域白质扩散成像变化与有限元应变测量之间的关系。对 102 个青少年足球主题赛季进行了赛季前和赛季后弥散加权成像，其中没有诊断出脑震荡。扩散数据根据 IXI 模板进行标准化。生成分数各向异性 (%ΔFA) 图像的百分比变化。使用头部碰撞遥测系统的数据，计算每个受试者的累积最大主应变一倍应变率 (CMPS1 × SR)，这是一个季节的累积拉伸脑应变和应变率的量度。进行了两次线性回归分析，以确定国际脑图白质掩模联盟内 CMPS1 × SR 和 %ΔFA 之间的显着正相关或负相关。年龄、体重指数、赛季前和赛季后成像之间的天数、既往脑损伤、注意力障碍诊断和成像方案都作为协变量包括在内。使用错误发现率校正，校正的 alpha 为 0.025，体素阈值为零。控制所有协变量，在双侧扣带回、穹窿、内囊、外囊、胼胝体、放射冠、皮质脊髓束、大脑和小脑中脚、上纵轴中发现 %ΔFA 和 CMPS1 × SR 之间存在显着的正线性关系。束和右额枕上束。 事后分析进一步证明，高应变足球受试者和非碰撞对照运动员之间存在显着的 %ΔFA 差异，低应变受试者和非碰撞对照运动员之间没有显着的 %ΔFA 差异，并且 CMPS1 × SR 显着解释了比头部数量更多的 %ΔFA 方差单独影响。