Marine mollusks are a prolific source of secondary metabolites with complex/diverse structures and various aspects of biological activities. For the above-mentioned reason, these animals have been extensively explored and have become the hotspot of the research subject in recent years. It is well documented that mollusks can escape from predation by utilizing bioactive metabolites as defensive chemicals. In the last decade, the possible diet relationship between the South China Sea mollusks and their related potential prey organisms, including sponges, corals, algae, etc. has been systematically investigated. A series of interesting results have been obtained concerning the chemistry, chemoecology, and pharmacological profiles of the studied marine organisms. The present review focuses on recent developments dealing with chemistry, chemoecology, and bioactivity of the South China Sea mollusks and their dietary organisms.

海洋软体动物是次级代谢产物的丰富来源，具有复杂/多样的结构以及生物活性的各个方面。由于上述原因，近年来已经对这些动物进行了广泛的探索，并成为研究主题的热点。有充分的文献记载，通过利用生物活性代谢物作为防御性化学物质，软体动物可以逃脱捕食。在过去的十年中，已经系统地研究了南海软体动物及其相关的潜在猎物生物（包括海绵，珊瑚，藻类等）之间可能的饮食关系。关于所研究海洋生物的化学，化学生态学和药理学特性，已经获得了一系列有趣的结果。本文的重点是化学，化学生态学，