An efficient, suitable and high yielding method has been developed for the synthesis of substituted piperidines via multicomponent, one-pot domino reaction of β-keto ester, aromatic amines, and aromatic aldehydes in the presence of catalytic amount of N-iodosuccinimide (NIS) in ethanol. Atom economy, mild reaction conditions, good to excellent yields, operational simplicity and easy work-up are some of the important features of this method.

中文翻译：

---

NIS 催化合成 1,2,3,4,6-五取代哌啶的多组分反应

在催化量的 N-碘代琥珀酰亚胺 (NIS) 存在下，通过β-酮酯、芳香胺和芳香醛的多组分单锅多米诺反应，开发了一种高效、合适且收率高的取代哌啶的合成方法在乙醇中。原子经济性、温和的反应条件、良好的收率、操作简单和易于后处理是该方法的一些重要特征。