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Effects of Brownian motions and thermophoresis diffusions on the hematocrit and LDL concentration/diameter of pulsatile non-Newtonian blood in abdominal aortic aneurysm
Journal of Non-Newtonian Fluid Mechanics ( IF 3.1 ) Pub Date : 2021-05-27 , DOI: 10.1016/j.jnnfm.2021.104576
Mohammad Abbasi , Amin Nadimian Esfahani , Ehsan Golab , Omid Golestanian , Nima Ashouri , S. Mohammad Sajadi , Ferial Ghaemi , Dumitru Baleanu , A. Karimipour

LDL concentration is believed to be responsible for plaque formation that leads to atherosclerotic cardiovascular disease. We conducted this study to investigate the effects of hematocrits and LDL diameters on LDL concentration on the wall of an abdominal aortic aneurysm (AAA). The blood flow was considered to be a pulsatile and non-Newtonian flow whose viscosity was a function of hematocrits and strain rate. Lumen, Brownian, and thermophoresis diffusions were analyzed in LDL concentration. The results demonstrated that adding thermophoresis diffusion increases LDL concentration. Moreover, among three types of LDLs, including small LDLs, intermediate LDLs, and large LDLs, small LDLs were the ones with the highest concentration at the wall of the aneurysm. Furthermore, the effects of vorticity on diffusions were examined; it could be noted that the maximum Brownian diffusion appeared in vorticity places. Our results indicated that Brownian diffusion declines as hematocrit reaches 45% whereas thermophoresis diffusion increases. The current simulation investigated the effects of hematocrits, vorticity, Brownian, and thermophoresis diffusions on LDL concentration on the wall. Three types of LDL were taken into account for investigation of the effects of the diameter and reference concentration on LDL concentration. The outcomes of this study could be summarized as the following: the maximum amount of the wall shear stress appeared at 0.2T and at the upstream end of the AAA; moreover, thermophoresis diffusion increased small LDL concentration by 26% on the wall for hematocrit 45%.



中文翻译:

布朗运动和热泳扩散对腹主动脉瘤中脉动非牛顿血液的血细胞比容和 LDL 浓度/直径的影响

低密度脂蛋白浓度被认为是导致动脉粥样硬化心血管疾病的斑块形成的原因。我们进行了这项研究,以研究血细胞比容和 LDL 直径对腹主动脉瘤 (AAA) 壁上 LDL 浓度的影响。血流被认为是脉动的非牛顿流,其粘度是血细胞比容和应变率的函数。以 LDL 浓度分析流明、布朗和热泳扩散。结果表明,添加热泳扩散会增加 LDL 浓度。此外,在小LDL、中LDL和大LDL三类LDL中,小LDL在动脉瘤壁浓度最高。此外,还检查了涡度对扩散的影响;可以看出,最大布朗扩散出现在涡度处。我们的结果表明,随着血细胞比容达到 45%,布朗扩散下降,而热泳扩散增加。当前的模拟研究了血细胞比容、涡度、布朗和热泳扩散对壁上 LDL 浓度的影响。考虑了三种类型的 LDL 来研究直径和参考浓度对 LDL 浓度的影响。本研究的结果可以概括如下:壁面剪应力的最大值出现在 0.2T 和 AAA 的上游端;此外,热泳扩散使壁上的小 LDL 浓度增加了 26%,血细胞比容为 45%。我们的结果表明,随着血细胞比容达到 45%,布朗扩散下降,而热泳扩散增加。当前的模拟研究了血细胞比容、涡度、布朗和热泳扩散对壁上 LDL 浓度的影响。考虑了三种类型的 LDL 来研究直径和参考浓度对 LDL 浓度的影响。本研究的结果可以概括如下:壁面剪应力的最大值出现在 0.2T 和 AAA 的上游端;此外,热泳扩散使壁上的小 LDL 浓度增加了 26%,血细胞比容为 45%。我们的结果表明,随着血细胞比容达到 45%,布朗扩散下降,而热泳扩散增加。当前的模拟研究了血细胞比容、涡度、布朗和热泳扩散对壁上 LDL 浓度的影响。考虑了三种类型的 LDL 来研究直径和参考浓度对 LDL 浓度的影响。本研究的结果可以概括如下:壁面剪应力的最大值出现在 0.2T 和 AAA 的上游端;此外,热泳扩散使壁上的小 LDL 浓度增加了 26%,血细胞比容为 45%。Brownian 和热泳扩散对壁上 LDL 浓度的影响。考虑了三种类型的 LDL 来研究直径和参考浓度对 LDL 浓度的影响。本研究的结果可以概括如下:壁面剪应力的最大值出现在 0.2T 和 AAA 的上游端;此外,热泳扩散使壁上的小 LDL 浓度增加了 26%,血细胞比容为 45%。Brownian 和热泳扩散对壁上 LDL 浓度的影响。考虑了三种类型的 LDL 来研究直径和参考浓度对 LDL 浓度的影响。本研究的结果可以概括如下:壁面剪应力的最大值出现在 0.2T 和 AAA 的上游端;此外,热泳扩散使壁上的小 LDL 浓度增加了 26%,血细胞比容为 45%。

更新日期:2021-06-03
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