Abstract

In this work, hydrogels with antimicrobial activity based on the polysaccharide maltodextrin (MD) were prepared by copolymerization with either acrylic acid (AAc) or acrylamide (AAm) to endow chemical functionality to host zinc oxide nanoparticles (ZnO). MD was previously modified with glycidyl methacrylate (GMA) in order to be susceptible to react with these monomers through free radical polymerization. The weight ratio of MD to the respective monomer was tuned in order to know its effect on the formation of a hydrogel. The preparation of these hydrogels was confirmed by Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), and X-ray diffraction (XRD). Swelling studies showed a better capacity to swell water for the polyacrylamide (PAAm)-containing hydrogels than those with polyacrylic acid (PAAc). These results were confirmed by the scanning electron microscopy (SEM) studies where the PAAm-containing hydrogels showed a 3D porous structure morphology with a bigger pore size than the PAAc-containing hydrogels. In addition, the energy-dispersive X-ray spectroscopy (EDX) demonstrated the presence of ZnO in the prepared hydrogels. ZnO-loaded hydrogels showed antimicrobial activity against Escherichia coli and Staphylococcus aureus. These results suggest that these hydrogels could be used in the biomedical area particularly as wound dressings due to their antimicrobial and swelling properties.

摘要

在这项工作中，基于多糖麦芽糖糊精 (MD) 的具有抗菌活性的水凝胶是通过与丙烯酸 (AAc) 或丙烯酰胺 (AAm) 共聚制备的，以赋予氧化锌纳米粒子 (ZnO) 的化学功能。MD 之前用甲基丙烯酸缩水甘油酯 (GMA) 改性，以便易于通过自由基聚合与这些单体反应。调整 MD 与相应单体的重量比，以了解其对水凝胶形成的影响。通过傅里叶变换红外光谱 (FT-IR)、热重分析 (TGA)、差示扫描量热法 (DSC) 和 X 射线衍射 (XRD) 证实了这些水凝胶的制备。溶胀研究表明，含聚丙烯酰胺 (PAAm) 的水凝胶比含聚丙烯酸 (PAAc) 的水凝胶具有更好的溶胀能力。这些结果通过扫描电子显微镜 (SEM) 研究得到证实，其中含 PAAm 的水凝胶显示出 3D 多孔结构形态，其孔径比含 PAAc 的水凝胶大。此外，能量色散 X 射线光谱 (EDX) 证明了制备的水凝胶中存在 ZnO。负载 ZnO 的水凝胶显示出抗微生物活性 能量色散 X 射线光谱 (EDX) 证明了制备的水凝胶中存在 ZnO。负载 ZnO 的水凝胶显示出抗微生物活性 能量色散 X 射线光谱 (EDX) 证明了制备的水凝胶中存在 ZnO。负载 ZnO 的水凝胶显示出抗微生物活性大肠杆菌和金黄色葡萄球菌。这些结果表明，这些水凝胶可用于生物医学领域，特别是作为伤口敷料，因为它们具有抗菌和溶胀特性。