The design of bioactive plasters is of major interest for the amelioration of dental and bone cements. In this article, a one pot and environmentally friendly strategy based on the addition of a cheap polyphenol-tannic acid (TA) or the main phenolic constituent of TA, namely pyrogallol (PY)- able to interact with calcium sulfate is proposed. Tannic acid and pyrogallol not only modify the morphology of the obtained plaster+TA/PY composites but a part of it is released and provides strong-up to twenty fold- antibacterial effect against Staphylococcus aureus. It is shown that the higher antibacterial efficiency of PY is related to a greater release compared to TA even if in solution the antibacterial effect of PY is lower than that of TA when reported on the basis of the molar concentration in PY units.

生物活性膏药的设计对于改善牙科和骨水泥具有重要意义。在本文中，提出了一种基于添加廉价的多酚 - 单宁酸 (TA) 或 TA 的主要酚类成分，即连苯三酚 (PY) - 能够与硫酸钙相互作用的单锅和环保策略。单宁酸和连苯三酚不仅改变了所获得的石膏+TA/PY 复合材料的形态，而且其中一部分被释放出来，对金黄色葡萄球菌提供高达 20 倍的强大抗菌作用。结果表明，与 TA 相比，PY 的较高抗菌效率与更大的释放有关，即使在溶液中 PY 的抗菌效果低于 TA 时，根据 PY 单位的摩尔浓度报告。