Introduction: The potential of the thyroid hormone receptor β (TRβ1) selective analog GC-1 has been widely proven in animal models and humans. However, its effect on the reproductive stage of the female rat has not been evaluated. Methods: The effect of the administration of GC-1 or equimolar doses of triiodothyronine (T3) was evaluated on the reproductive performance of the hypothyroid female rat and the indirect effect on pup thyroid status, weight, and survival. Results: Hypothyroidism reduced the number of embryos implanted in the uterus, whereas T3 and GC-1 treatment in hypothyroid females reestablished the number of implanted embryos to normal. Initiation of labor was delayed by hypothyroidism, and T3 replacement treatment reinstated the normal timing of parturition. The administration of GC-1 alone to the lactating mother did not affect pup survival, weight, or thyroidal status. Conclusions: Our findings show the differential effect of thyroid hormone selective signaling during gestation and the indirect exposure of the pups; we also emphasize the plausible use of GC-1 for treatment of hypothyroid mothers during the lactation period.
Eur Thyroid J

中文翻译：

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拟甲状腺素 GC-1 选择性信号传导对甲状腺功能减退大鼠生殖和哺乳性能的影响

简介：甲状腺激素受体 β (TRβ1) 选择性类似物 GC-1 的潜力已在动物模型和人体中得到广泛证实。然而，尚未评估其对雌性大鼠生殖阶段的影响。方法：评估给予 GC-1 或等摩尔剂量的三碘甲状腺原氨酸 (T3) 对甲状腺功能减退雌性大鼠生殖性能的影响以及对幼犬甲状腺状态、体重和存活的间接影响。结果：甲状腺功能减退减少了植入子宫的胚胎数量，而甲状腺功能减退女性的 T3 和 GC-1 治疗使植入的胚胎数量恢复正常。分娩开始因甲状腺功能减退而延迟，T3 替代治疗恢复了正常的分娩时间。对哺乳期母亲单独使用 GC-1 不会影响幼犬的存活率、体重或甲状腺状态。结论：我们的研究结果显示了妊娠期间甲状腺激素选择性信号传导和幼崽间接暴露的不同影响；我们还强调了在哺乳期使用 GC-1 治疗甲状腺功能减退母亲的合理性。
欧洲甲状腺杂志