Background: The thalamus is known as the central sensory and motor relay station of the brain generally. However, cognitive decline due to thalamic lesions has been previously reported in different studies. Also, it has been observed that different cognitive subdomains are affected according to the localization of the lesion in the thalamus. Objectives and Methods: Detailed neurophysiological tests were performed on 28 patients with thalamic hemorrhage and the control group. Patients were grouped according to lesion localization. The results were compared with both the control group and the hemorrhage groups themselves. Results: The performance of patients in all neuropsychological tests was significantly worse than that of the control group. Of the 28 patients, 15 had anterolateral, 5 had posterolateral, 5 had dorsal, and 3 had an anteromedial thalamic hemorrhage. The anteromedial group had the worst scores of almost all tests. Also, 2 situations came to notice in these tests. First, the posterolateral group achieved a remarkably low mean in the recall subgroup of the MMSE tests and verbal memory process tests. Second, the anterolateral group was found to have a low mean in both the language subgroup of the MMSE tests and the phonemic subgroup of the verbal fluency tests. Conclusion: It was concluded in this study that thalamic hemorrhages affect cognition entirely regardless of the lesion localization. It was also observed that the lateral part of the thalamus was associated with language, the posterior part with memory, and the anteromedial part with the rest of the cognitive subdomains.
Dement Geriatr Cogn Disord Extra 2021;11:129–133

中文翻译：

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根据病变定位的丘脑出血患者的认知概况

背景：丘脑通常被称为大脑的中枢感觉和运动中继站。然而，先前在不同的研究中报道过丘脑病变导致的认知能力下降。此外，据观察，根据丘脑病变的定位，不同的认知子域受到影响。目的和方法：对28例丘脑出血患者和对照组进行详细的神经生理学检查。根据病变部位对患者进行分组。将结果与对照组和出血组本身进行比较。结果：患者在各项神经心理学测试中的表现均显着差于对照组。28 例患者中，15 例为前外侧出血，5 例为后外侧出血，5 例为背侧出血，3 例为丘脑前内侧出血。前内侧组几乎在所有测试中得分最差。此外，在这些测试中还注意到两种情况。首先，后外侧组在 MMSE 测试和言语记忆过程测试的回忆亚组中取得了非常低的平均值。其次，发现前外侧组在 MMSE 测试的语言亚组和言语流畅性测试的音素亚组中均值较低。结论：本研究得出的结论是，无论病变部位如何，丘脑出血都会完全影响认知。还观察到丘脑的外侧部分与语言相关，后部与记忆相关，前内侧部分与其余认知子域相关。
痴呆老年认知障碍额外 2021 年；11：129–133