Ample proof showed that non-coding RNAs (ncRNAs) play a crucial role in proliferation and differentiation of osteoblasts and bone marrow stromal cells (BMSCs). Varied forms of biophysical stimuli like mechanical strain, fluid shear stress (FSS), microgravity and vibration are verified to regulate ncRNAs expression in osteogenic differentiation and influence the expression of target genes associated with osteogenic differentiation and ultimately regulate bone formation. The consequences of biophysical stimulation on osteogenic differentiation validate the prospect of exercise for the prevention and treatment of osteoporosis. In this review, we tend to summarize the studies on regulation of osteogenic differentiation by ncRNAs beneath biophysical stimulation and facilitate to reveal the regulatory mechanism of biophysical stimulation on ncRNAs, and provide an update for the prevention of bone metabolism diseases by exercise.

中文翻译：

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生物物理刺激对成骨分化的影响和ncRNAs的机制

大量证据表明，非编码 RNA (ncRNA) 在成骨细胞和骨髓基质细胞 (BMSC) 的增殖和分化中起着至关重要的作用。验证了各种形式的生物物理刺激，如机械应变、流体剪切应力 (FSS)、微重力和振动，以调节成骨分化中 ncRNA 的表达，并影响与成骨分化相关的靶基因的表达，并最终调节骨形成。生物物理刺激对成骨分化的影响验证了运动预防和治疗骨质疏松症的前景。在这篇综述中，我们倾向于总结ncRNAs在生物物理刺激下调控成骨分化的研究，并有助于揭示生物物理刺激对ncRNAs的调控机制，