Graphene Family Nanomaterials in Ocular Applications: Physicochemical Properties and Toxicity,Chemical Research in Toxicology

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Graphene Family Nanomaterials in Ocular Applications: Physicochemical Properties and Toxicity
Chemical Research in Toxicology ( IF 3.7 ) Pub Date : 2021-05-27 , DOI: 10.1021/acs.chemrestox.0c00340
Sedigheh Borandeh ₁ , Vahid Alimardani ₂ , Samira Sadat Abolmaali ₂ , Jukka Seppälä ₁

Affiliation

Graphene family nanomaterials (GFNs) are rapidly emerging for ocular applications due to their outstanding physicochemical properties. Since the eyes are very sensitive organs and the contact between the eyes and GFNs in eye drops, contact lenses, intraocular drug delivery systems and biosensors and even the workers handling these nanomaterials is inevitable, it is necessary to investigate their ocular toxicities and physiological interactions with cells as well as their toxicity mechanisms. The toxicity of GFNs can be extremely affected by their physicochemical properties, including composition, size, surface chemistry, and oxidation level as well as dose and the time of exposure. Up to now, there are several studies on the in vitro and in vivo toxicity of GFNs; however, a comprehensive review on ocular toxicity and applications of GFNs is missing, and a knowledge about the health risks of eye exposure to the GFNs is predominantly unspecified. This review highlights the ocular applications of GFNs and systematically covers the most recent advances of GFNs’ physicochemical properties, in vitro and in vivo ocular toxicity, and the possible toxicity mechanisms as well as provides some perspectives on the potential risks of GFNs in material development and biomedical applications.

中文翻译：

眼科应用中的石墨烯家族纳米材料：理化性质和毒性

石墨烯家族纳米材料 (GFN) 由于其出色的物理化学特性而迅速出现在眼科应用中。由于眼睛是非常敏感的器官，眼睛与滴眼液、隐形眼镜、眼内给药系统和生物传感器中的 GFNs 甚至处理这些纳米材料的工人之间的接触是不可避免的，因此有必要研究它们的眼部毒性和生理相互作用。细胞及其毒性机制。GFNs 的毒性受其理化特性的极大影响，包括组成、大小、表面化学和氧化水平以及剂量和暴露时间。迄今为止，已有多项关于体外和体内GFNs 的毒性；然而，缺少对 GFNs 的眼部毒性和应用的全面审查，并且关于眼睛暴露于 GFNs 的健康风险的知识主要是未指明的。这篇综述重点介绍了 GFNs 的眼部应用，并系统地涵盖了 GFNs 理化性质、体外和体内眼部毒性以及可能的毒性机制的最新进展，并就 GFNs 在材料开发和研究中的潜在风险提供了一些观点。生物医学应用。

更新日期：2021-06-21

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