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14,17,18-Trihydroxy-Eicosatetraenoic Acid: A Novel Pro-Resolving Lipid Mediator from Marine Microalgae
ACS Pharmacology & Translational Science ( IF 4.9 ) Pub Date : 2021-05-27 , DOI: 10.1021/acsptsci.1c00057 Hans Jagusch 1 , Markus Werner 2 , Duco Koenis 3 , Jesmond Dalli 3 , Oliver Werz 2 , Georg Pohnert 1
ACS Pharmacology & Translational Science ( IF 4.9 ) Pub Date : 2021-05-27 , DOI: 10.1021/acsptsci.1c00057 Hans Jagusch 1 , Markus Werner 2 , Duco Koenis 3 , Jesmond Dalli 3 , Oliver Werz 2 , Georg Pohnert 1
Affiliation
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Specialized pro-resolving mediators (SPMs) are enzymatically oxygenated derivatives of polyunsaturated fatty acids that function as central immunoregulators in mammals. Among them are resolvins (Rvs) that stimulate the clearance of harmful stimuli and limit pro-inflammatory processes. Because of their beneficial features and their high potency, SPMs are promising molecules for anti-inflammatory therapy. Besides mammals, also marine algae form lipid mediators such as prostaglandins and leukotrienes. In particular, microalgae are attractive candidates for the production of bioactive high-value metabolites. Here, we identified the diatom Cylindrotheca closterium as a prolific producer of SPMs. The diatom forms RvE3 and novel structurally related eicosanoids, including 14S/R,17R,18R-trihydroxy-eicosatetraenoic acid, which displays inflammation-resolving and anti-inflammatory bioactivities. This pro-resolving compound might enable advancements in anti-inflammatory therapy in mammals.
中文翻译：
14,17,18-三羟基-二十碳四烯酸：一种来自海洋微藻的新型促分解脂质介质
专门的促分解介质 (SPM) 是多不饱和脂肪酸的酶氧化衍生物，在哺乳动物中起中枢免疫调节剂的作用。其中包括刺激清除有害刺激和限制促炎过程的分解素 (Rvs)。由于它们的有益特性和高效力，SPM 是用于抗炎治疗的有前途的分子。除了哺乳动物，海藻还形成脂质介质，例如前列腺素和白三烯。特别是，微藻是生产具有生物活性的高价值代谢物的有吸引力的候选者。在这里，我们将硅藻Cylindrotheca closterium确定为 SPM 的多产生产者。硅藻形成 RvE3 和新型结构相关的类花生酸，包括 14 S / R,17 R ,18 R-三羟基-二十碳四烯酸，具有消炎和抗炎的生物活性。这种促分解化合物可能会促进哺乳动物的抗炎治疗。
更新日期：2021-06-11
中文翻译：
14,17,18-三羟基-二十碳四烯酸：一种来自海洋微藻的新型促分解脂质介质
专门的促分解介质 (SPM) 是多不饱和脂肪酸的酶氧化衍生物，在哺乳动物中起中枢免疫调节剂的作用。其中包括刺激清除有害刺激和限制促炎过程的分解素 (Rvs)。由于它们的有益特性和高效力，SPM 是用于抗炎治疗的有前途的分子。除了哺乳动物，海藻还形成脂质介质，例如前列腺素和白三烯。特别是，微藻是生产具有生物活性的高价值代谢物的有吸引力的候选者。在这里，我们将硅藻Cylindrotheca closterium确定为 SPM 的多产生产者。硅藻形成 RvE3 和新型结构相关的类花生酸，包括 14 S / R,17 R ,18 R-三羟基-二十碳四烯酸，具有消炎和抗炎的生物活性。这种促分解化合物可能会促进哺乳动物的抗炎治疗。
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