Abstract

Resveratrol is well known for its antioxidant potential and ability to preserve mitochondrial function, reported attenuating ischemia-reperfusion (IR) injury in the heart. The present study investigates resveratrol on IR injury in rat hearts treated with statin for 14 days. Male Wistar rats were used in this study, and statin-induced cardiac metabolic alterations were monitored after the administration of simvastatin (80 mg/kg). IR was instigated by the Langendroff perfusion system and measured the physiological and biochemical changes. The basal level changes in ECG, ANP, and BNP expression and CoenzymeQ₁₀ level were altered in statin-treated animals compared to the normal rat heart. The animals treated with statin demonstrated higher IR injury (measured via low rate pressure product (88.4%), increased histological alterations, prominent mitochondrial dysfunction (NQR: IR-72%, Stat IR-67%; SQR: IR-71%, Stat IR-74%; COX: IR-58%, Stat IR-52%) than the normal rat heart underwent similar protocols. Administration of heart with resveratrol recovered the IR associated hemodynamic indices in normal heart subjected to IR but failed to impart a similar effect in the statin-treated heart. Our results demonstrated that resveratrol failed to reverse the IR-associated cardiac injury and functional abnormalities in statin-treated rat hearts subjected to IR but effective in IR challenged normal heart.

摘要

白藜芦醇以其抗氧化潜力和保护线粒体功能的能力而闻名，据报道它可以减轻心脏的缺血再灌注 (IR) 损伤。本研究调查了白藜芦醇对用他汀类药物治疗 14 天的大鼠心脏 IR 损伤的影响。本研究使用雄性 Wistar 大鼠，在给予辛伐他汀 (80 mg/kg) 后监测他汀类药物诱导的心脏代谢变化。IR 由 Langendroff 灌注系统发起并测量生理和生化变化。_{ECG、ANP 和 BNP 表达和 CoenzymeQ 10}的基础水平变化与正常大鼠心脏相比，他汀类药物治疗的动物的水平发生了变化。用他汀类药物治疗的动物表现出更高的 IR 损伤（通过低速率压力产品测量 (88.4%)、增加的组织学改变、显着的线粒体功能障碍 (NQR: IR-72%, Stat IR-67%; SQR: IR-71%, Stat IR-74%; COX: IR-58%, Stat IR-52%) 比正常大鼠心脏经历了类似的方案。用白藜芦醇的心脏管理恢复了正常心脏的 IR 相关血流动力学指标，但未能给予类似的在他汀类药物治疗的心脏中的作用我们的结果表明，白藜芦醇未能逆转他汀类药物治疗的大鼠心脏受到 IR 的 IR 相关心脏损伤和功能异常，但对 IR 攻击的正常心脏有效。