Although chemotherapeutics are considered as genotoxins for decades, their exact mutagenic impact on the genome of cancerous and normal cells of cancer patients was unknown for a long time. However, this knowledge is necessary to understand the long-term side effects of chemotherapy. A particular condition represents pregnant cancer patients being treated with chemotherapy. Since certain chemotherapeutics can cross the placenta, concerns exist about possible mutational effects on the fetus' genome with potential long-term health consequences.

中文翻译：

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基于下一代测序的新型方法学，用于表征非癌组织中（产前）化疗暴露的突变后果。

尽管几十年来化疗药物都被认为是基因毒素，但长期以来，它们对癌症患者的癌细胞和正常细胞基因组的确切诱变影响尚不清楚。然而，这些知识对于了解化疗的长期副作用是必要的。一种特殊情况代表正在接受化疗的怀孕癌症患者。由于某些化疗药物可以穿过胎盘，因此人们担心可能会对胎儿基因组产生突变影响，从而产生潜在的长期健康后果。