Introduction: Staphylococcus lugdunensis (SL), a tube coagulase negative Staphylococcus , is known to be pathogenic in adults, causing mainly skin infections. Gap Statement: Previous studies assessing SL's role in paediatric populations are sparse and are mainly limited to case reports. Aim: Present the clinical characteristics consistent with SL infections and its putative role as a pathogen in the paediatric population. Methodology: A retrospective multicentre study was conducted in four paediatric medical centres in Israel. Patients with isolates of SL presenting between 2009–2019 were included. Results: SL was isolated from 40 patients. Average (±SD) age at presentation was 5.9 (±6.2) years, with 22 (55 %) being female. Skin, soft tissue and musculoskeletal infections were the most common (n=20, 50%) followed by ear infections (n=13, 32.5%). Five cases of urine isolates and two isolates from blood culture samples were also reported. Skin abscess was the most common infection among skin and soft tissue isolates, reported in 17 children (85%) with SL being the only pathogen in 15 (75%). Otitis media was the most common ear infection accounting for 12 (92%) of all cases with SL as the only isolate reported in 6 (46%). Five cases of SL isolates from urine specimens were reported, all of which with poor growth of bacteria and normal urinalysis. Two cases of SL growth in blood culture were found in children presenting with signs and symptoms consistent with invasive blood stream infection. Conclusions: In the paediatric population, studied infections caused by SL are increasingly observed. The results of this study highlight its role as a pathogen in soft tissue infections and its putative role in otitis media and invasive blood stream infections. However, the role of SL as an uropathogen was not established.

中文翻译：

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Lugdunensis葡萄球菌作为儿童病原体的作用：多中心回顾性研究

简介： 已知链球菌凝固酶阴性的葡萄球菌葡萄球菌（SL）是成年人的致病菌，主要引起皮肤感染。差距声明：先前评估SL在儿科人群中的作用的研究很少，主要限于病例报告。目的：介绍与SL感染相一致的临床特征及其在儿童人群中作为病原体的假定作用。方法：在以色列的四个儿科医学中心进行了一项回顾性多中心研究。包括2009-2019年间出现SL分离株的患者。结果： 从40例患者中分离出SL。报告时的平均年龄为5.9（±6.2）岁，女性为22（55％）。皮肤，软组织和肌肉骨骼感染最常见（n = 20，50％），其次是耳部感染（n= 13，32.5％）。还报告了5例尿液分离株和2例血培养样品分离株。皮肤脓肿是皮肤和软组织分离物中最常见的感染，据报道有17名儿童（85％）患有SL，SL是15名儿童中唯一的病原体（75％）。中耳炎是最常见的耳部感染，占所有病例中的12例（92％），其中SL是唯一的分离菌，占6例（46％）。据报道，从尿液标本中分离出5例SL分离物，所有这些细菌均生长缓慢且尿液分析正常。在儿童中发现了2例SL的血液培养生长情况，这些儿童的症状和体征与侵入性血流感染相符。结论：在儿科人群中，越来越多地观察到由SL引起的已研究感染。这项研究的结果突出了其在软组织感染中作为病原体的作用以及在中耳炎和侵入性血流感染中的假定作用。但是，SL作为尿路致病菌的作用尚未确立。