Fifteen Klebsiella pneumoniae isolates harbouring bla NDM genes were identified from blood and sputum specimens of patients at a tertiary-care facility (Yangon General Hospital, Yangon, Myanmar) in 2018. Two of the isolates belonged to sequence type (ST) 11, an international high-risk clone. Whole-genome sequencing and phylogenetic analyses revealed that these two isolates were clustered together with other ST11 isolates originating from other countries. The isolates harboured the bla NDM-5 gene on an IncFII-type plasmid that is prevalent among carbapenemase-producing Enterobacteriaceae in Yangon but has rarely been found in other ST11 isolates. Our data suggests the regional presence of the ST11 international high-risk clone and its acquisition of an endemic bla NDM-5-carrying plasmid.

中文翻译：

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从缅甸三级医院仰光总医院临床样本中分离出的携带blaNDM-5的肺炎克雷伯菌肺炎克雷伯菌11型国际高风险克隆

2018年，在一家三级医疗机构（仰光，缅甸仰光），从患者的血液和痰标本中鉴定出15株带有bla NDM基因的肺炎克雷伯菌分离株。其中两个分离株属于序列类型（ST）11，国际高风险克隆。全基因组测序和系统发育分析表明，这两个分离株与其他国家的ST11分离株聚在一起。分离株在生产碳青霉烯酶的肠杆菌科中普遍存在的IncFII型质粒上带有bla NDM-5基因 在仰光，但在其他ST11分离株中很少发现。我们的数据表明ST11国际高风险克隆的区域性存在及其对地方bla NDM-5携带质粒的获取。