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Membrane molecules for mood
Trends in Neurosciences ( IF 14.6 ) Pub Date : 2021-05-27 , DOI: 10.1016/j.tins.2021.05.001 David A Slattery 1 , John F Cryan 2
中文翻译:
情绪的膜分子
更新日期:2021-07-27
Trends in Neurosciences ( IF 14.6 ) Pub Date : 2021-05-27 , DOI: 10.1016/j.tins.2021.05.001 David A Slattery 1 , John F Cryan 2
Affiliation
According to the decades-old neurotrophic hypothesis of depression, the delayed actions of antidepressants are purported to be due to their downstream effects on neuronal plasticity. In a recent study, Casarotto et al. reveal that antidepressants can in fact directly bind to the neurotrophin TRKB receptor and exert their effects through this mechanism.
中文翻译:
情绪的膜分子
根据已有数十年历史的抑郁症神经营养假说,抗抑郁药的延迟作用据称是由于它们对神经元可塑性的下游影响。在最近的一项研究中,卡萨罗托等人。揭示抗抑郁药实际上可以直接与神经营养蛋白 TRKB 受体结合并通过这种机制发挥作用。