Abstract

Neuroendocrine neoplasms (NENs) constitute a heterogeneous group of tumors. In this review, we summarize the results of various clinical trials that have been conducted to investigate the efficacy and safety of various therapeutic options for NENs. Based on the encouraging results obtained from these trials, various therapeutic options have been established for the treatment of NENs, including somatostatin analogs (SSAs), molecularly targeted drugs and cytotoxic agents. In addition, peptide receptor radionucleotide therapy has recently been evaluated for the treatment of various NENs. We also discuss the approach for selecting the appropriate drugs and sequence of treatment with the various drug classes, as recommended by different treatment guidelines. Finally, we discuss the scope for future research in this field, especially into the merits of combination therapy with molecularly targeted drugs plus SSAs, along with ongoing studies.

中文翻译：

---

胃肠胰神经内分泌肿瘤的医疗现状及未来展望

摘要

神经内分泌肿瘤（NEN）是一组异质性肿瘤。在这篇综述中，我们总结了为研究 NEN 各种治疗方案的有效性和安全性而进行的各种临床试验的结果。基于这些试验获得的令人鼓舞的结果，已经建立了治疗 NEN 的各种治疗方案，包括生长抑素类似物 (SSA)、分子靶向药物和细胞毒药物。此外，肽受体放射性核苷酸疗法最近已针对各种 NEN 的治疗进行了评估。我们还讨论了根据不同治疗指南的建议选择适当药物的方法以及不同药物类别的治疗顺序。最后，我们讨论了该领域未来研究的范围，特别是分子靶向药物加 SSA 联合治疗的优点以及正在进行的研究。