Purpose

To evaluate the changes in visual function and anterior surface aberrations during soft contact lens (SCL) wear after the instillation of hyaluronic acid (HA) eye drops with different viscosity.

Methods

A prospective, randomized, and participant-masked study was performed. Twenty healthy participants (25.4 ± 2.6 years) were evaluated. Hydrogel (Ocufilcon D) and silicone-hydrogel (Somofilcon A) SCL were randomly assigned to both eyes of the same participant. Visual function in terms of high- and low-contrast corrected distance visual acuity (CDVA) and anterior contact lens surface aberrations (RMS HOA) were measured before and after the instillation, at different times, of different eye drops: saline (control) and 0.1%, 0.2%, and 0.3% HA.

Results

Compared with the saline solution, during hydrogel SCL wear, there was an improvement (P < 0.05) in high-contrast CDVA after 3 and 10 min with 0.1% HA, and after 5 and 20 min with 0.2% HA. During silicone-hydrogel SCL wear, there was a deterioration (P < 0.05) in high-contrast CDVA after 1 and 30 min with 0.3% HA. Additionally, during silicone-hydrogel SCL wear, there was also a deterioration (P < 0.05) in low-contrast CDVA after 5 and 20 min with 0.3% HA. In terms of RMS HOA, there were no clinically relevant changes with both SCL.

Conclusions

The instillation of HA eye drops could have a different effect on visual quality depending on their concentration of HA, the contact lens material, its surface ionicity, or other physicochemical properties that should be studied in future studies.

中文翻译：

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滴注透明质酸滴眼液后软性隐形眼镜视觉质量的变化

目的

评估在滴注不同粘度的透明质酸 (HA) 滴眼液后佩戴软性隐形眼镜 (SCL) 期间视觉功能和前表面像差的变化。

方法

进行了一项前瞻性、随机和参与者不知情的研究。评估了 20 名健康参与者（25.4 ± 2.6 岁）。水凝胶 (Ocufilcon D) 和硅水凝胶 (Somofilcon A) SCL 随机分配给同一参与者的双眼。在滴注不同滴眼液之前和之后，在不同时间测量不同滴眼液：生理盐水（对照）和0.1%、0.2% 和 0.3% HA。

结果

与盐水溶液相比，在水凝胶 SCL 磨损期间，使用 0.1% HA 3 和 10 分钟后，以及使用 0.2% HA 5 和 20 分钟后，高对比度 CDVA 有改善（P < 0.05）。在硅水凝胶 SCL 磨损期间，使用 0.3% HA 1 和 30 分钟后，高对比度 CDVA 出现恶化（P < 0.05）。此外，在硅水凝胶 SCL 磨损期间，使用 0.3% HA 5 和 20 分钟后，低对比度 CDVA 也出现恶化（P < 0.05）。就 RMS HOA 而言，两种 SCL 都没有临床相关的变化。

结论

HA 滴眼液的滴注可能对视觉质量产生不同的影响，这取决于它们的 HA 浓度、隐形眼镜材料、其表面离子性或应在未来研究中研究的其他物理化学特性。