Gamma-delta (γδ) T cells are the bridge between natural and adaptive immunity. In the present study, peripheral blood was collected from 13 patients with advanced schistosomiasis (schistosomiasis group) and 13 uninfected people (control group) to investigate the γδ T cells and their subtypes in human schistosomiasis. Compared with the control group, the proportion of Vδ1 cells and CD27⁺Vδ1⁺ cells in the schistosomiasis group increased significantly, while CD27⁻ cells and CD27⁻Vδ1⁻ cells decreased. Only the level of IL-17A differed between the groups, being significantly decreased in the schistosomiasis group. In the schistosomiasis group, there were no correlations between the liver fibrosis and subsets of γδ T cells, or the level of cytokines. Additionally, the level of IL-17A correlated positively with the proportion of CD27⁻ Vδ1⁻ cells. Thus, there was a higher frequency of circulating Vδ1 γδT cells in patients with advanced schistosomiasis. The decreased IL-17A might be related to the reduction in CD27⁻Vδ1⁻ cell.

中文翻译：

---

晚期血吸虫病患者循环Vδ1γδT细胞频率较高

γ-δ (γδ) T 细胞是天然免疫和适应性免疫之间的桥梁。本研究采集13名晚期血吸虫病患者（血吸虫病组）和13名未感染者（对照组）的外周血，研究人血吸虫病中的γδT细胞及其亚型。与对照组相比，血吸虫病组Vδ1细胞和CD27 ⁺ Vδ1 ^{+细胞的比例显着增加，而CD27 -}细胞和CD27 ^- Vδ1 ^-细胞减少。各组之间只有 IL-17A 水平不同，血吸虫病组显着降低。在血吸虫病组中，肝纤维化与γδT细胞亚群或细胞因子水平之间没有相关性。^{此外，IL-17A 的水平与 CD27 -} Vδ1 ^-细胞的比例呈正相关。因此，晚期血吸虫病患者的循环 Vδ1 γδT 细胞频率较高。IL-17A 减少可能与 CD27 ^- Vδ1 ^-细胞减少有关。