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The neural mechanism of spatial-positional association in working memory: A fMRI study
Brain and Cognition ( IF 2.2 ) Pub Date : 2021-05-26 , DOI: 10.1016/j.bandc.2021.105756
Dandan Zhou 1 , Qing Cai 2 , Jie Luo 3 , Zizhen Yi 3 , Yun Li 3 , Carol A Seger 4 , Qi Chen 3
Affiliation  

In the last decade, research has reported that items at the beginning of a memorized sequence are responded to faster with the left hand, whereas items at the end are responded to faster with the right hand. This Spatial-Positional Associations of Response Codes effect has been extensively studied using behavioral methods. However, the neural networks underlying it remain unclear. We found using functional magnetic resonance imaging (fMRI) that the dorsal attention network was involved in spatial-positional associations, in particular a region of the right superior frontal cortex / pre-supplementary motor area (pre-SMA), within which neural activity correlated with behavioral measures of the strength of spatial-positional associations. Psychophysiological interaction (PPI) analysis revealed functional connectivity between this area and other regions of the dorsal attentional network including the SMA, and with the hippocampal-retrosplenial network. In contrast, explicit processing of serial order independent of spatial-positional associations was related to activity in the inferior parietal cortex. Our results provide new insight into positional coding theories of working memory, including the mental whiteboard hypothesis. They suggest that the behavioral effects of positional coding (congruency between hand and ordinal position within the list) are mediated through spatial and motor control maps in the dorsal attentional system.



中文翻译:

工作记忆中空间位置关联的神经机制:功能磁共振成像研究

在过去的十年中,研究表明左手对记忆序列开头的项目反应更快,而右手对结尾的项目反应更快。已经使用行为方法对响应代码效应的这种空间位置关联进行了广泛研究。然而,其背后的神经网络仍不清楚。我们使用功能磁共振成像 (fMRI) 发现,背侧注意力网络参与空间位置关联,特别是右侧上额叶皮层/前辅助运动区 (pre-SMA) 的区域,其中神经活动相关与空间位置关联强度的行为测量。心理生理学相互作用 (PPI) 分析揭示了该区域与包括 SMA 在内的背侧注意网络的其他区域以及海马-后脑网络之间的功能连接。相比之下,独立于空间位置关联的序列顺序的显式处理与下顶叶皮层的活动有关。我们的研究结果为工作记忆的位置编码理论提供了新的见解,包括心理白板假设。他们认为位置编码的行为影响(列表中手和顺序位置之间的一致性)是通过背侧注意系统中的空间和运动控制图来调节的。独立于空间位置关联的序列顺序的显式处理与下顶叶皮层的活动有关。我们的研究结果为工作记忆的位置编码理论提供了新的见解,包括心理白板假设。他们认为位置编码的行为影响(列表中手和顺序位置之间的一致性)是通过背侧注意系统中的空间和运动控制图来调节的。独立于空间位置关联的序列顺序的显式处理与下顶叶皮层的活动有关。我们的研究结果为工作记忆的位置编码理论提供了新的见解,包括心理白板假设。他们认为位置编码的行为影响(列表中手和顺序位置之间的一致性)是通过背侧注意系统中的空间和运动控制图来调节的。

更新日期:2021-05-26
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