ABSTRACT

Introduction: Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by cutaneous and systemic inflammation and barrier abnormalities. Over the past few decades, proteomic studies have been increasingly applied to AD research to compliment transcriptomic evaluations. Proteomic analyses helped identify new biomarkers of AD, allowing investigation of both the cutaneous AD profile and the systemic inflammation associated with the disease.

Areas covered: This review discusses key studies that utilized various proteomic technologies to analyze AD skin and/or blood, which facilitated discovery of biomarkers related to pathogenesis, disease severity, systemic inflammation, and therapeutic response. Moreover, this review summarizes proteomic studies that helped define various AD endotypes/phenotypes. A literature search was conducted by querying Scopus, Google Scholar, PubMed/Medline, and Clinicaltrials.gov up to January 2021.

Expert opinion: Use of proteomics in AD has allowed for identification of novel AD-related protein biomarkers. This approach continues to evolve and is becoming increasingly common for the study of AD, in conjunction with other -omics platforms, as proteomics shifts to quicker and more sensitive methods for detection of potential protein biomarkers. Although many biomarkers have been identified thus far, future larger studies are necessary to further correlate these markers with clinical parameters.

摘要

简介: 特应性皮炎 (AD) 是一种慢性炎症性皮肤病，其特征是皮肤和全身炎症以及屏障异常。在过去的几十年中，蛋白质组学研究越来越多地应用于 AD 研究，以补充转录组学评估。蛋白质组学分析有助于识别 AD 的新生物标志物，从而可以研究皮肤 AD 特征和与疾病相关的全身炎症。

涵盖的领域：本综述讨论了利用各种蛋白质组学技术分析 AD 皮肤和/或血液的关键研究，这有助于发现与发病机制、疾病严重程度、全身炎症和治疗反应相关的生物标志物。此外，本综述总结了有助于定义各种 AD 内型/表型的蛋白质组学研究。截至 2021 年 1 月，通过查询 Scopus、Google Scholar、PubMed/Medline 和 Clinicaltrials.gov 进行了文献检索。

专家意见：在 AD 中使用蛋白质组学可以识别新的 AD 相关蛋白质生物标志物。随着蛋白质组学转向更快、更灵敏的检测潜在蛋白质生物标志物的方法，这种方法不断发展，并且与其他组学平台一起在 AD 研究中变得越来越普遍。尽管迄今为止已经确定了许多生物标志物，但未来需要进行更大规模的研究以进一步将这些标志物与临床参数相关联。