ABSTRACT

Introduction

As the prevalence of drug-resistant infections continues to outpace the development of new antibiotics, we must explore all reasonable options for enhancing the effectiveness of existing anti-infectives. The emergence of novel pathogens without initial drug treatments or vaccines, typified by the severe acute respiratory syndrome coronavirus-2 pandemic, further underscores the need for non-pharmacologic adjunctive measures for infection management. Osteopathic manipulative treatment (OMT) may represent such an adjunct.

Areas Covered

PubMed, CINAHL, Google Scholar, Cochrane databases and relevant chapters of major osteopathic texts were searched for animal experiments, case reports, observational studies, non-randomized, and randomized trials pertaining to infection, OMT, and the complications or safety of OMT. OMT was associated with one or more of the following: decreased bacterial colony counts in lung tissue; changes in immunologic profiles manifested by significant differences dendritic cells and levels of IL-8, MCP-1, MIP-1a, and G-CSF; shorter durations of IV antibiotics; decreased length of hospitalization; decreased rates of respiratory failure and death; decreased post-surgical lengths of stay; and enhanced patient satisfaction.

Expert Opinion

Preliminary, lower-grade evidence suggests that OMT can improve some infection-related outcomes, and is safe. The role of OMT in infection management should undergo further controlled trials without delay.

中文翻译：

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将整骨手法治疗纳入感染管理的基本原理：诠释学综述

摘要

介绍

随着耐药性感染的流行继续超过新抗生素的开发速度，我们必须探索所有合理的选择，以提高现有抗感染药物的有效性。没有初始药物治疗或疫苗的新型病原体的出现，以严重急性呼吸综合征冠状病毒 2 大流行为代表，进一步强调了对感染管理采取非药物辅助措施的必要性。整骨手法治疗 (OMT) 可能代表了这种辅助手段。

涵盖的领域

搜索了 PubMed、CINAHL、Google Scholar、Cochrane 数据库和主要整骨疗法文本的相关章节，以查找与感染、OMT 以及 OMT 并发症或安全性有关的动物实验、病例报告、观察性研究、非随机和随机试验。OMT 与以下一项或多项相关：肺组织中细菌菌落计数减少；免疫学特征的变化表现为树突状细胞和 IL-8、MCP-1、MIP-1a 和 G-CSF 水平的显着差异；IV抗生素的持续时间更短; 住院时间缩短；呼吸衰竭和死亡率降低；减少术后住院时间；并提高患者满意度。

专家意见

初步的、低级别的证据表明，OMT 可以改善一些与感染相关的结果，并且是安全的。OMT 在感染管理中的作用应立即进行进一步的对照试验。