Combination of peptides with biological, organic, and inorganic materials for synergistically enhanced diagnostics and therapeutics,Peptide Science

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Combination of peptides with biological, organic, and inorganic materials for synergistically enhanced diagnostics and therapeutics
Peptide Science ( IF 1.5 ) Pub Date : 2021-05-26 , DOI: 10.1002/pep2.24233
Joo‐Young Kim _{1,

2} , Jae Yun Lee ₁ , Ha Yeon Park ₁ , Hyunji Kim ₁ , Jeon Hyeong Kang ₁ , Hyun Jin Kim _{1,

2} , Woo‐Jin Jeong _{1,

2}

Affiliation

Armed with the useful properties of small molecules and proteins, peptides hold the potential to be utilized in almost all biomedical research fields. However, the clinical application of peptides has been limited due to their intrinsic drawbacks, such as poor plasma stability and low target binding affinity. The conjugation of peptides to biological, organic (nonbiological), and inorganic materials has recently emerged as a promising strategy to address these problems. Hence, in this article, we provide an overview of the successful outcomes of using peptide-bio/organic/inorganic conjugates in various biomedical applications, including the diagnosis and treatment of diseases.

中文翻译：

肽与生物、有机和无机材料的组合用于协同增强诊断和治疗

凭借小分子和蛋白质的有用特性，肽具有用于几乎所有生物医学研究领域的潜力。然而，肽的临床应用由于其固有的缺点而受到限制，例如血浆稳定性差和靶标结合亲和力低。肽与生物、有机（非生物）和无机材料的结合最近已成为解决这些问题的有前途的策略。因此，在本文中，我们概述了在各种生物医学应用（包括疾病的诊断和治疗）中使用肽-生物/有机/无机缀合物的成功结果。

更新日期：2021-05-26

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