Though questions about whether gene editing should be done at all have dominated ethical discussion, a literature about how it can be done ethically has been growing. Work on responsible translational pathways for human germline gene editing has been criticized for focusing on the wrong questions. But questions about responsible translational pathways—questions about how gene editing could be done ethically—are, in an important sense, prior to questions about whether it is desirable and permissible. Asking “whether” questions about gene editing requires a model of what responsible clinical use of gene editing would look like.

中文翻译：

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基因编辑：如果你不知道“如何”，你怎么能问“是否”？

尽管关于是否应该进行基因编辑的问题主导了伦理讨论，但关于如何以伦理方式进行基因编辑的文献一直在增长。人类种系基因编辑负责任的翻译途径的工作因关注错误的问题而受到批评。但从某种重要意义上说，关于负责任的翻译途径的问题——关于如何合乎道德地进行基因编辑的问题——先于关于基因编辑是否可取和允许的问题。提出有关基因编辑“是否”的问题需要一个负责任的临床使用基因编辑的模型。