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Differential effects from cognitive rehabilitation and high-definition tDCS in posterior cortical atrophy: A single-case experimental design
Neuropsychological Rehabilitation ( IF 1.7 ) Pub Date : 2021-05-26 , DOI: 10.1080/09602011.2021.1927761
Christine Sofka Dugas 1 , Elena Keltner-Dorman 1 , John Hart 1, 2, 3
Affiliation  

ABSTRACT

Posterior cortical atrophy (PCA) is a progressive neurodegenerative syndrome characterized by visual-perceptual deficits, which impact daily life. Recent research has focused on non-pharmacological techniques to ameliorate these deficits, with the most common being cognitive rehabilitation. The present study investigates the differential effects of high definition-transcranial direct current stimulation (HD-tDCS) and cognitive rehabilitation in a single-case experimental design with two separate experimental phases in a patient with PCA. Experimental Phase 1 consisted of 10 sessions of HD-tDCS targeting the pre-SMA/dACC and Phase 2 consisted of 10 sessions of cognitive rehabilitation. Normed and standardized scores from figure copy and recall tests served as the primary outcome measures for visuospatial processing. The participant showed no immediate or long-term changes in visuospatial measures following HD-tDCS intervention. However, cognitive rehabilitation showed immediate improvement in visuospatial memory (figure recall) and clinically significant improvement in visuospatial construction (figure copy). Visuospatial construction gains remained in the low average range in the 10-week follow-up while visuospatial memory returned to baseline. Results indicated differential effects between HD-tDCS and cognitive rehabilitation with cognitive rehabilitation showing clinically significant improvement in primary outcome measures with sustained improvement in the long-term follow-up measure. Additional research is warranted to confirm these effects.



中文翻译:

认知康复和高清 tDCS 对后皮质萎缩的不同影响:单例实验设计

摘要

后皮质萎缩 (PCA) 是一种进行性神经退行性综合征,其特征是视觉感知缺陷,影响日常生活。最近的研究集中在改善这些缺陷的非药物技术上,最常见的是认知康复。本研究调查了高清晰度经颅直流电刺激 (HD-tDCS) 和认知康复在 PCA 患者中具有两个独立实验阶段的单病例实验设计的不同效果。实验阶段 1 包括 10 次针对前 SMA/dACC 的 HD-tDCS,阶段 2 包括 10 次认知康复。图形复制和回忆测试的标准化和标准化分数作为视觉空间处理的主要结果测量。在 HD-tDCS 干预后,参与者的视觉空间测量没有立即或长期的变化。然而,认知康复显示视觉空间记忆(图形回忆)的立即改善和视觉空间构造的临床显着改善(图形复制)。在 10 周的随访中,视觉空间构建增益保持在较低的平均范围内,而视觉空间记忆恢复到基线。结果表明,HD-tDCS 和认知康复之间的差异效应与认知康复显示主要结果测量的临床显着改善和长期随访测量的持续改善。需要进一步的研究来证实这些影响。认知康复显示视觉空间记忆(图回忆)的立即改善和视觉空间构造的临床显着改善(图复制)。在 10 周的随访中,视觉空间构建增益保持在较低的平均范围内,而视觉空间记忆恢复到基线。结果表明,HD-tDCS 和认知康复之间的差异效应与认知康复显示主要结果测量的临床显着改善和长期随访测量的持续改善。需要进一步的研究来证实这些影响。认知康复显示视觉空间记忆(图回忆)的立即改善和视觉空间构造的临床显着改善(图复制)。在 10 周的随访中,视觉空间构建增益保持在较低的平均范围内,而视觉空间记忆恢复到基线。结果表明,HD-tDCS 和认知康复之间的差异效应与认知康复显示主要结果测量的临床显着改善和长期随访测量的持续改善。需要进一步的研究来证实这些影响。在 10 周的随访中,视觉空间构建增益保持在较低的平均范围内,而视觉空间记忆恢复到基线。结果表明,HD-tDCS 和认知康复之间的差异效应与认知康复显示主要结果测量的临床显着改善和长期随访测量的持续改善。需要进一步的研究来证实这些影响。在 10 周的随访中,视觉空间构建增益保持在较低的平均范围内,而视觉空间记忆恢复到基线。结果表明,HD-tDCS 和认知康复之间的差异效应与认知康复显示主要结果测量的临床显着改善和长期随访测量的持续改善。需要进一步的研究来证实这些影响。

更新日期:2021-05-26
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