Tomato is one of the most consumable vegetable crops worldwide. The crop is affected by several pathogens and early blight disease is one of the most deleterious diseases that can severely affect tomato foliage. The current study was carried out to evaluate the effectiveness of the endophytic fungi Trichoderma viride and Chaetomium globosum to manage the early blight disease of tomato and to assess the plant innate defense response to the biocontrol agents application. Results revealed that foliar application of T. viride and C. globosum either alone or in combination reduced disease incidence by 73.3, 37.6, 59.1% respectively while disease severity reached 18.7, 46.4, 37.6% compared to control plants. At the same time, the treatments increased tomato growth significantly both the shoot fresh weight at a rate of 32, 9, 25% and root fresh weight at a rate of 54, 18, 27% of T . viride, C. globosum and the mixture of the two fungi respectively. Consequently, the shoot and root dry weights were increased as compared to control plants. Measurements of physiological and biochemical parameters exhibited a substantial increase in chlorophyll contents (Chl a, Chl b, Total chl) but a decrease in hydrogen peroxide (H₂O₂), membrane ion leakage, and Malondialdehyde (MDA) levels at 48 and 96 h post treatments. Furthermore, assessment of the antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) revealed a substantial enhancement of the SOD enzymatic activities reached 3, 1.8, 2.6 folds at day 3 and 5.2, 2.8, 3.8 folds at day 5 post treatments for T. viride, C. globosum and the mixture of the two fungi respectively whereas the increase in CAT activities reached 4.6, 2.3, 2.6 folds at day 3 and 16, 9.5, 9.5 folds at day 5 of the same treatments respectively. Subsequently, it was concluded that the two fungi were able to protect tomato plants against A. alternata via suppression of disease incidence, enhancement of chlorophyll contents, improvement of the plant health and induction of tomato innate defense system. Generally, T. viride was more effective in controlling early blight disease over C. globosum alone or in combination with T. viride. There was no synergistic interaction observed.

番茄是世界上消耗量最大的蔬菜作物之一。作物受到多种病原体的影响，早疫病是最有害的疾病之一，可严重影响番茄叶子。目前的研究旨在评估内生真菌绿色木霉和球毛壳菌防治番茄早疫病的有效性，并评估植物对生物防治剂应用的先天防御反应。结果表明，叶面喷施绿色木霉和球藻与对照植物相比，单独或组合使疾病发生率分别降低了 73.3、37.6、59.1%，而疾病严重程度分别达到 18.7、46.4、37.6%。同时，处理显着增加了番茄的生长，茎部鲜重分别为 32%、9%、25% 和根部鲜重，分别为T的 54%、18%、27% 。viride、C. globosum和这两种真菌的混合物。因此，与对照植物相比，地上部和根的干重增加。生理和生化参数的测量显示叶绿素含量（Chl a、Chl b、总 chl）显着增加，但过氧化氢（H ₂ O ₂)、膜离子泄漏和处理后 48 小时和 96 小时的丙二醛 (MDA) 水平。此外，对抗氧化酶超氧化物歧化酶 (SOD) 和过氧化氢酶 (CAT) 的评估显示，SOD 酶活性在第 3 天显着增强，达到 3、1.8、2.6 倍，在T处理后第 5 天达到 5.2、2.8、3.8 倍。. viride、C. globosum和两种真菌的混合物，而 CAT 活性在相同处理的第 3 天分别增加了 4.6、2.3、2.6 倍，在第 5 天分别增加了 16、9.5、9.5 倍。随后，得出结论，这两种真菌能够保护番茄植株免受A. alternata通过抑制发病率、提高叶绿素含量、改善植物健康和诱导番茄先天防御系统。一般来说，T. viride在控制早疫病方面比单独使用C. globosum或与T. viride组合更有效。没有观察到协同相互作用。