The development of metal nanoparticle-based facile colorimetric assays for drugs and insecticides is an emerging area of current scientific research. In the present work, polypropylene glycol was used for stabilization of gold nanoparticles (AuNPs) in a simple one-pot two-phase process and subsequently employed it for the specific detection of cephradine (CPH). The characterization of the prepared PPG-AuNPs was conducted through various analytical techniques such as UV-visible spectrophotometry, Fourier transform infrared spectroscopy, atomic force microscopy (AFM), zeta potential and zetasizer techniques. As the major target of the study, the stabilized PPG-AuNPs were employed for colorimetric detection of CPH and other drugs. Typical wine-red colour of PPG-AuNPs disappeared immediately and surface plasmon resonance band quenched by addition of CPH in the presence of several other interferents (drugs and salts) and in real samples. PPG-AuNPs permitted efficient, selective, reliable and rapid determination in a concentration range of 0.01–120 mM with a detection limit (LoD) of 11.0 mM. The developed sensor has the potential to be used for fast scanning of pharmaceutical formulations for quantification of CPH at production facilities.

基于金属纳米粒子的药物和杀虫剂简便比色测定的开发是当前科学研究的一个新兴领域。在目前的工作中，聚丙二醇用于在简单的一锅两相过程中稳定金纳米粒子（AuNP），随后将其用于头孢拉定（CPH）的特异性检测。通过各种分析技术对制备的 PPG-AuNPs 进行表征，如紫外可见分光光度法、傅里叶变换红外光谱法、原子力显微镜 (AFM)、zeta 电位和 zetasizer 技术。作为该研究的主要目标，稳定的 PPG-AuNPs 用于 CPH 和其他药物的比色检测。在存在几种其他干扰物（药物和盐）的情况下以及在实际样品中，PPG-AuNP 的典型酒红色立即消失，并且通过添加 CPH 来猝灭表面等离子体共振带。 PPG-AuNPs 可以在 0.01–120 mM 的浓度范围内进行高效、选择性、可靠和快速的测定，检测限 (LoD) 为 11.0 mM。开发的传感器有潜力用于快速扫描药物配方，以量化生产设施中的 CPH。