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Radiation recall dermatitis following letrozole administration in patient with a remote history of radiation therapy
npj Breast Cancer ( IF 6.5 ) Pub Date : 2021-05-26 , DOI: 10.1038/s41523-021-00271-3
Evan Sweren 1 , Pathik Aravind 2 , Robert Dembinski 2 , Catherine Klein 2 , Mehran Habibi 2 , Michelle L Kerns 1
Affiliation  

We report the case of letrozole-induced radiation recall dermatitis (RRD) in a patient with a remote history of radiation therapy. There is only one previously known case of RRD triggered by letrozole in a patient with a recent (<3 month) history of radiation. Previously, only four other cases of aromatase-inhibitor-induced RRD have been reported. This case is significant for cancer care teams considering personalized treatments. In addition, improved long-term outcomes in cancer patients may lead to increases in and underdiagnoses of RRD. Likewise, RRD is patient specific, exacerbating health concerns, and can be difficult to recognize without proper awareness, documentation, and classification of triggering drugs. The authors hope to address these issues in this report.



中文翻译:

有远期放射治疗史的患者服用来曲唑后出现放射回忆性皮炎

我们报告了一名有长期放射治疗史的患者出现来曲唑诱发的放射回忆性皮炎 (RRD) 的病例。此前已知只有一例由来曲唑引发的 RRD 病例,患者近期(<3 个月)有放射史。此前,仅报道了四例芳香酶抑制剂诱发的 RRD 病例。这个案例对于考虑个性化治疗的癌症护理团队来说具有重要意义。此外,癌症患者长期预后的改善可能会导致 RRD 的增加和漏诊。同样,RRD 是针对患者的,会加剧健康问题,并且如果没有适当的认识、记录和触发药物分类,可能很难识别。作者希望在本报告中解决这些问题。

更新日期:2021-05-26
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