Purpose To explore the risk factors for ophthalmic artery (OA) stenosis and occlusion after intra-arterial chemotherapy (IAC) with selective ophthalmic artery catheterisation (OAC) in the treatment of retinoblastoma. Design Retrospective, single centre case-control study. Methods The study was conducted including consecutive patients with unilateral or bilateral intraocular retinoblastoma undergoing IAC between June 2016 and June 2019 with a follow-up time of 4 years. Main outcomes are rate of IAC-induced OA occlusion and OA diameter. Results 346 attempted OAC infusions were successful. The total incidence of OA occlusion was 15.89%. The occlusion and control groups were similar in patients’ age, sex and disease stage. Median OA diameter was 0.49 mm in those with OA occlusion, and 0.66 mm in those without occlusion. In the occlusion group, the OA diameter difference was significantly larger between the first IAC and the final IAC (0.22mm vs 0.12mm, p=0.001). In both groups, the median number of IAC treatments was 3. Multivariate Cox regression models included initial OA diameter (OR: 0.005, p=0.001), ratio of OA orifice diameter differences between first and last IAC to the initial OA orifice diameter (OR: 4.661, p=0.003), and number of IAC (OR: 1.538, p=0.042) as clinical features significantly associated with OA occlusion. Conclusions The OA diameter at first IAC treatment, the ratio of OA orifice diameter differences between first and last IAC to the initial OA orifice diameter and total number of IAC treatments may be three main clinical predictors for OA occlusion after IAC for retinoblastoma. All data relevant to the study are included in the article or uploaded as supplementary information. All free text entered below will be published.

中文翻译：

---

动脉内化疗治疗视网膜母细胞瘤患者眼动脉狭窄闭塞的危险因素

目的探讨选择性眼动脉导管插入术（OAC）动脉内化疗（IAC）治疗视网膜母细胞瘤后眼动脉（OA）狭窄和闭塞的危险因素。设计回顾性单中心病例对照研究。方法 研究对象为 2016 年 6 月至 2019 年 6 月连续接受 IAC 的单侧或双侧眼内视网膜母细胞瘤患者，随访时间为 4 年。主要结果是 IAC 引起的 OA 闭塞率和 OA 直径。结果 346 次尝试 OAC 输注成功。OA闭塞的总发生率为15.89%。闭塞组和对照组在患者年龄、性别和疾病分期方面相似。OA 闭塞患者的中位 OA 直径为 0.49 mm，而无闭塞患者的中位 OA 直径为 0.66 mm。在遮挡组中，第一个 IAC 和最终 IAC 之间的 OA 直径差异显着更大（0.22 毫米对 0.12 毫米，p = 0.001）。在两组中，IAC 治疗的中位数为 3。多变量 Cox 回归模型包括初始 OA 直径（OR：0.005，p=0.001），第一次和最后一次 IAC 之间的 OA 孔直径差异与初始 OA 孔直径的比率（OR : 4.661, p=0.003) 和 IAC 数量 (OR: 1.538, p=0.042) 作为与 OA 闭塞显着相关的临床特征。结论 首次IAC治疗时的OA直径、首次IAC与末次IAC的OA孔直径差异与初始OA孔直径的比值以及IAC治疗的总次数可能是IAC治疗视网膜母细胞瘤后OA闭塞的三个主要临床预测指标。所有与研究相关的数据都包含在文章中或作为补充信息上传。下面输入的所有自由文本都将被发布。