The development of two-dimensional (2D) transition metal dichalcogenides has been in a rapid growth phase for the utilization in surface-enhanced Raman scattering (SERS) analysis. Here, we report a promising 2D transition metal tellurides (TMTs) material, hafnium ditelluride (${\mathrm{HfTe}}_2$), as an ultrasensitive platform for Raman identification of trace molecules, which demonstrates extraordinary SERS activity in sensitivity, uniformity, and reproducibility. The highest Raman enhancement factor of $2.32\times {10}^6$ is attained for a rhodamine 6G molecule through the highly efficient charge transfer process at the interface between the ${\mathrm{HfTe}}_2$ layered structure and the adsorbed molecules. At the same time, we provide an effective route for large-scale preparation of SERS substrates in practical applications via a facile stripping strategy. Further application of the nanosheets for reliable, rapid, and label-free SERS fingerprint analysis of uric acid molecules, one of the biomarkers associated with gout disease, is performed, which indicates arresting SERS signals with the limits of detection as low as 0.1 mmol/L. The study based on this type of 2D SERS substrate not only reveals the feasibility of applying TMTs to SERS analysis, but also paves the way for nanodiagnostics, especially early marker detection.

中文翻译：

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层状二碲化铪作为超灵敏表面增强拉曼散射平台，用于无标记检测尿酸

二维 (2D) 过渡金属二硫属化物的开发已处于快速增长阶段，以用于表面增强拉曼散射 (SERS) 分析。在这里，我们报告了一种很有前途的二维过渡金属碲化物（TMTs）材料，二碲化铪（${铽}_2$)，作为用于痕量分子拉曼鉴定的超灵敏平台，在灵敏度、均匀性和重现性方面表现出非凡的 SERS 活性。最高拉曼增强因子$2.32\times {10}^6$ 罗丹明 6G 分子通过在其界面处的高效电荷转移过程获得 ${铽}_2$层状结构和吸附分子。同时，我们通过简便的剥离策略为实际应用中大规模制备 SERS 衬底提供了有效途径。进一步应用纳米片对尿酸分子进行可靠、快速和无标记的 SERS 指纹分析，尿酸分子是与痛风疾病相关的生物标志物之一，这表明抑制 SERS 信号的检测限低至 0.1 mmol/ L。基于这种2D SERS基底的研究不仅揭示了将TMTs应用于SERS分析的可行性，而且为纳米诊断，尤其是早期标志物检测铺平了道路。