The role of ligand endocytosis in notch signalling,Biology of the Cell

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The role of ligand endocytosis in notch signalling
Biology of the Cell ( IF 2.4 ) Pub Date : 2021-05-26 , DOI: 10.1111/boc.202100009
Ekaterina Seib ₁ , Thomas Klein ₁

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The Notch signalling receptor is a mechanoreceptor that is activated by force. This force elicits a conformational change in Notch that results in the release of its intracellular domain into the cytosol by two consecutive proteolytic cleavages. In most cases, the force is generated by pulling of the ligands on the receptor upon their endocytosis. In this review, we summarise recent work that shed a more detailed light on the role of endocytosis during ligand-dependent Notch activation and discuss the role of ubiquitylation of the ligands during this process.

中文翻译：

配体内吞作用在缺口信号传导中的作用

Notch 信号受体是一种被强制激活的机械感受器。这种力引起 Notch 的构象变化，导致其细胞内结构域通过两个连续的蛋白水解切割释放到细胞质中。在大多数情况下，力是通过在受体内吞作用时拉动受体上的配体产生的。在这篇综述中，我们总结了最近的工作，这些工作更详细地阐明了内吞作用在配体依赖性 Notch 激活过程中的作用，并讨论了配体泛素化在此过程中的作用。

更新日期：2021-05-26

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