Introduction
The aim of this study was to present a case of complete clinical response of renal clear cell carcinoma cutaneous metastases after high-dose-rate surface brachytherapy (HDR sBT).

Material and methods
An 81-year-old female diagnosed with stage IV clear cell renal carcinoma reported to our center with painful relapse of two cutaneous metastases after a previous metastasectomy. The patient was disqualified from systemic therapy due to comorbidities, and qualified to attempt a treatment using HDR sBT. The unit equipped with an iridium-192 source was used to deliver 36 Gy/6 Gy in 6 fractions twice weekly. Overall treatment time was 18 days.

Results
Two weeks after HDR sBT, complete response was observed in one irradiated location, while the partial response was observed in the latter. EORTC grade 1 skin toxicity was reported in both irradiated fields. Three and five months after the treatment, the patient presented complete response and pain relief in both locations with no signs of relapse. The patient remained in palliative care and died seven months after the treatment due to sudden cardiac death.

Conclusions
HDR sBT can be a valuable treatment option for cutaneous metastatic renal cell carcinoma, especially for patients with significant comorbidities. The treatment provided was associated with low toxicity and excellent clinical outcome.



中文翻译：

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高剂量率表面近距离放射治疗作为肾细胞癌皮肤转移的治疗选择

简介
本研究的目的是介绍一例在高剂量率表面近距离放射治疗 (HDR sBT) 后肾透明细胞癌皮肤转移完全临床缓解的病例。

材料和方法
一名 81 岁的女性被诊断为 IV 期透明细胞肾癌，向我们中心报告了在先前的转移灶切除术后两个皮肤转移灶复发的痛苦。由于合并症，该患者被取消了全身治疗的资格，并有资格尝试使用 HDR sBT 进行治疗。配备铱 192 源的装置用于每周两次以 6 个部分提供 36 Gy/6 Gy。总治疗时间为18天。

结果
HDR sBT 两周后，在一个照射位置观察到完全反应，而在后者观察到部分反应。在两个辐照区域均报告了 EORTC 1 级皮肤毒性。治疗 3 个月和 5 个月后，患者在两个部位均表现出完全缓解和疼痛缓解，没有复发迹象。患者继续接受姑息治疗，治疗 7 个月后因心源性猝死而死亡。

结论
HDR sBT 可以成为皮肤转移性肾细胞癌的一种有价值的治疗选择，特别是对于有严重合并症的患者。所提供的治疗与低毒性和出色的临床结果相关。