Distinct DNA methylation patterns have recently been observed to precede type 1 diabetes in whole blood collected from young children. Our aim was to determine, whether perinatal DNA methylation could be associated with later progression to type 1 diabetes. Reduced representation bisulfite sequencing (RRBS) analysis was performed on umbilical cord blood samples collected within the Type 1 Diabetes Prediction and Prevention (DIPP) study. Children later diagnosed with type 1 diabetes and/or testing positive for multiple islet autoantibodies (N=43) were compared to control individuals (N=79), who remained autoantibody-negative throughout the DIPP follow-up until 15 years of age. Potential confounding factors related to the pregnancy and the mother were included in the analysis. No differences in the cord blood methylation patterns were observed between these cases and controls.

中文翻译：

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后来发展为 1 型糖尿病的儿童的脐带血 DNA 甲基化

最近在从幼儿收集的全血中观察到不同的 DNA 甲基化模式发生在 1 型糖尿病之前。我们的目的是确定围产期 DNA 甲基化是否与后来发展为 1 型糖尿病有关。对 1 型糖尿病预测和预防 (DIPP) 研究中收集的脐带血样本进行了减少代表性亚硫酸氢盐测序 (RRBS) 分析。后来诊断为 1 型糖尿病和/或多种胰岛自身抗体检测呈阳性的儿童 (N=43) 与对照个体 (N=79) 进行比较，后者在整个 DIPP 随访期间自身抗体呈阴性，直至 15 岁。与怀孕和母亲有关的潜在混杂因素也包括在分析中。