Abstract

Compound 1-(3-amino-4-morpholino-1H-indazole-1-carbonyl)-N-(4-methoxyphenyl)cyclopropane-1-carboxamide (C₂₂H₂₃N₅O₃, M_r = 870.96) was synthesized by condensation of 1-(4-methoxyphenylcarbamoyl)cyclopropane-1-carboxylic acid with 4-morpholino-1H-indazol-3-amine, which was prepared from 2,6-difluorobenzonitrile by amination with morpholine and subsequent cyclization with hydrazine hydrate. The crystal structure was determined. The results of biological activity determination indicated that the compound exhibited significant inhibitory activity against some cancer cell lines.

中文翻译：

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具有抗增殖活性的分子1-（3-氨基-4-Morpholino-1H-吲唑-1-羰基）-N-（4-甲氧基苯基）环丙烷-1-羧酰胺的合成和晶体结构

摘要

化合物1-（3-氨基-4-吗啉代-1 H-吲唑-1-羰基）-N-（4-甲氧基苯基）环丙烷-1-羧酰胺（C ₂₂ H ₂₃ N ₅ O ₃，M _r = 870.96）为1-（4-甲氧基苯基氨基甲酰基）环丙烷-1-甲酸与4-吗啉代-1 H-吲唑-3-胺的缩合反应，合成的方法是由2,6-二氟苄腈经吗啉胺化，然后与水合肼环合。确定了晶体结构。生物活性测定的结果表明该化合物对某些癌细胞系显示出显着的抑制活性。